INTRODUCTION Acrylic resins containing acrylic acid (AA), methyl methacrylate (MMA) or acrylic–methacrylic copolymer are the most commonly used polymeric materials for biomedical and pharmaceutical applications owing to their hydrophilicity and biocompatibility.1–4 Recently, a new polyvinyl alcohol (PVA) copolymer designed by copolymerizing AA and MMA with PVA was successfully developed as a ca...

Bletilla striata polysaccharides (BSPs) have been used in pharmaceutical and biomedical industry, the aim of the present study was to explore a BSPs amphiphilic derivative to overcome its application limit as poorly water-soluble drug carriers due to water-soluble polymers. Stearic acid (SA) was selected as a hydrophobic block to modify B. striata polysaccharides (SA-BSPs). Docetaxel (DTX)-load...

This study demonstrates the selective tumor targeting and the antitumor efficacy of the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound mesochlorin e6 monoethylenediamine (Mce6) and HPMA copolymer-bound Adriamycin (ADR) in combination photodynamic therapy (PDT) and chemotherapy against human ovarian OVCAR-3 carcinoma xenografted in female athynmic mice. The concentrations of Mce6 and A...

hydrolysis of ethylene-vinyl acetate copolymer in alkaline conditions using two systems of naoh/methanol and koh/isopropanol has been studied and the formation of ethylene-vinyl alcohol copolymer was systematically examined using nmr spectroscopy and dsc measurements. vinyl acetate weight percentage and the degree of hydrolysis were calculated from nmr spectroscopy and it is shown that hydrolys...

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Unmodified [60]fullerenes (C60) were solubilised with high stability using various type of poly(ethylene glycol) (PEG) based block copolymer micelles. Block copolymer micelle-incorporated C60 fullerenes were studied in cultures for biological activities using human cervical cancer HeLa cells. As a result, the cationic block copolymer micelles delivered C60 into the cells depending on their surf...

Although block copolymer motifs have received considerable attention as supramolecular templates for inorganic nanoparticles, experimental observations of a nanostructured diblock copolymer containing inorganic nanoparticles-supported by theoretical trends predicted from a hybrid self-consistent field/density functional theory-confirm that nanoparticle size and selectivity can likewise stabiliz...

9-nitrocamptothecin (9-nc) is a semisynthetic and a low soluble analogue of camptothecin alkaloids that target nuclear enzyme topoisomerase i. the unstable lactone form of 9-nc in biological fluids requires for its cytotoxic activity. to improve aqueous solubility and stability in biological media, 9-nc was loaded in polymeric nanoparticles. in this paper, we studied the effect of peg percent (...

ionomers are generally described by copolymers having either acrylic or methacylic acid as one component and the other component is mostly either ethylene or styrene. the objective of this research was to study the thermal behaviour and stability of ionomers of styrene with some alkali metal acrylates. these materials have been synthesized by neutralization of the respective copolymer containin...

Sulfur copolymer nanowires have been reported for the first time as highly stable visible-light-active photocatalysts for photoelectrochemical water splitting depending on their size and sulfur content. The as-prepared sulfur copolymer nanowires can serve as a sulfur source and templates to create metal sulfide/copolymer heterocatalysts.