Coombs' negative autoimmune hemolytic anemia (AIHA) is a rare disease which shares similar clinical and hematological features with Coombs' positive AIHA, but its exact frequency remains unknown. There have been few reports of idiopathic thrombocytopenic purpura (ITP) and Coombs' negative AIHA associated with other lymphoproliferative disorders (LPDs). Since there is a well known association be...

Although positive direct Coombs' tests occur in most patients with active systemic lupus erythematosus (SLE), haemolytic anaemic associated with antibody to erythrocytes (E) occurs in less than 10%. Our studies show an association between positive direct Coombs' tests and both the presence of circulating immune complexes and diminished activity of the C3b receptor (CR1) of E. Data presented in ...

Model Generative Reasoning (MGR) is a problem solving architecture designed to support AI applications in unstructured task environments, i.e. in task environments in which the statistical quality, completeness, and relevance of the data that will be available to the problem solver at any particular time cannot be predicted reliably (Hartley et al., 1987; Coombs and Hartley, in press a; Coombs ...

The relationship between blood groups and some infections such as norovirus, cholera, and malaria has been reported. Despite the importance of brucellosis, there is a lack of data on the relationship between blood groups and brucellosis. Thus, in this study, we examined the relationship between blood groups and brucellosis. In this case-control study, the blood groups of 100 patients with bruce...

BACKGROUND Many serological tests have been used for the diagnosis of human brucellosis. A new serological method is identified as Brucella Coombs gel test based on the principle of centrifugation gel system similar to the gel system used in blood group determination. In this system, if Brucella antibodies were present in the serum, antigen and antibody would remain as a pink complex on the gel...

Abstract Brucellosis is one of the most important zoonosis. It causes significant economic and medical problems in countries throughout the world, including Iran. According to the available literature, brucellosis rarely causes intracranial space-occupying lesions. In this case study, we reported an intracranial mass in a 52-year-old male who were affected with brucellosis. The patient was ref...

Acquired haemolytic anaemia in childhood is a relatively uncommon condition. Lederer (1925) described three patients with acute haemolytic anaemia and in the literature up to 1938 Atkinson (1940) found 59 cases of 'Lederer's anaemia', 30 of which were in children. Millichap (1952) reviewed the papers published between 1940 and 1951 and found reports of a further 32 children with this disorder, ...

The BrucellaCapt test is an immunocapture agglutination test suggested as a possible substitute for the Coombs test in the diagnosis of human brucellosis. Here it is compared with classical tests using 321 samples from 48 patients with brucellosis (6.9 +/- 1.7 samples per patient), including 20 patients with focal disease and 8 patients with a total of 9 relapse episodes (mean follow-up, 18 mon...