The paper aims to explore, theoretically and empirically, the creation of orgnizational knowledge in the virtual context, in which geographically dispersed individuals communicate through Information and Communication Technologies (ICTs). The paper brings together the writings of Vygotsky, Bakhtin, Schön and Goffman to argue that knowledge creation involves the continuous effort of individuals ...

One of the fundamental events in metamorphosis in insects is the replacement of larval tissues by imaginal tissues. Shortly after pupariation the imaginal discs evaginate to assume their positions at the surface of the prepupal animal. This is a very precise process that is only beginning to be understood. In Drosophila, during embryonic dorsal closure, the epithelial cells push the amnioserosa...

“The web site is down”. These five words can induce a panic attack in even the most seasoned and level-headed network administrator. Every second of downtime costs money, potentially damages customer relationships, and inhibits new customers. And, to add insult to injury, it is not possible to contact the users to tell them what’s going on because they are nameless, faceless, people located som...

Morphological diversity of leg appendages is one of the hallmarks of developmental evolution. Limbs in insects may develop either from their embryonic prototypes or from imaginal discs harbored inside the larva. Bombyx mori (B. mori), a Lepidopteran insect, develops adult wings from larval wing imaginal discs. However, it has been debated whether the adult legs of B. mori arise from imaginal di...

A Data Warehouse (DW) can be used to integrate data from multiple distributed data sources. A DW can be seen as a set of materialized views that determine its schema and its content in terms of the schema and the content of the data sources. DW applications require high query performance. For this reason, the design of a typical DW consists of selecting views to materialize that are able to ans...

In holometabolous development, higher insects pass through two stages, the larva and the imago. Both larval and imaginal cells are derived from the cells of the blastoderm stage. After the final embryonic wave of mitosis, however, only the imaginal cells remain diploid and capable of division, proliferate massively and do not differentiate. The development of the imaginal discs in Dacus tryoni ...

Many of the functions required for formation of the imaginal discs of Drosophila melanogaster larvae, from which adult structures are derived, are disc-specific and not required for formation of other larval tissues. Mutants blocked in disc-specific functions can produce mature viable larvae, indicating that larval development is not dependent on concomitant disc development. Some of the mutant...

Mutations in the escargot (esg) locus, which codes for a zinc-finger-containing protein with similarity to the product of the snail gene, cause a variety of defects in adult structures such as loss of abdominal cuticle and malformation of the wings and legs. esg RNA is expressed in wing, haltere, leg and genital imaginal discs and in abdominal histoblast nests in the embryo. Expression in imagi...

Boundary Element Associated Factor-32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are lethal, show loss of epithelial morphology in imaginal discs and cause neoplastic growth defects. To investigate the molecular mechanisms underlying this phenotype, we carried out a genome-wide analys...