We analysed microsatellite genotypes sampled from the Pakistani and Indian communities in Nottingham, UK, to investigate the genetic consequences of substructuring mediated by traditional marriage customs. The application of a recently developed likelihood approach identified significant levels of population substructure within the Pakistani community as a whole, as well as within the finer div...

Consanguineous unions have been associated with an increased susceptibility to various forms of inherited disease. Although consanguinity is known to contribute to recessive diseases, the potential role of consanguinity in certain common birth defects is less clear, particularly since the disease pathophysiology may involve genetic and environmental/epigenetic factors. In this study, we ask whe...

consanguineous marriages are traditionally favoured in most of asian and african countries especially in the muslim countries. however, it is apparent that these kinds of marriage are a major factor of some genetic disorders inherited in an autosomal recessive pattern. although there is a long history of consanguineous marriage in iran, the information on its prevalence is too poor. the aim of ...

Genetic diseases in the Tunisian population represent a real problem of public health as their spectrum encompasses more than 400 disorders. Their frequency and distribution in the country have been influenced by demographic, economic and social features especially consanguinity. In this article, we report on genetic disease association referred to as comorbidity and discuss factors influencing...

Consanguineous marriages are respected and practiced among more than one billion of the world’s populationwith consanguinity rates reaching 20–50%. Consanguinity increases risk congenital anomalies, autosomalrecessive disorders, perinatal antenatal morbidities. This study determines knowledge regardingconsanguineous its genetic effects young adults.Objectives: 1. To assess regarding consanguine...

Introduction Marriage between close biological kin is not regarded as advantageous in the western world but in other parts of the world, consanguineous unions persist. Consanguineous marriage increases the birth prevalence of individuals with recessive disorders. In Accra, Ghana, consanguinity is beginning to emerge as a significant cause of rare neurological disease at the central referral hos...

Arranged marriage is where parents choose marital partners for their children. It is a norm in many parts of Asia and Middle East. A marriage is said to be consanguineous where the marriages are solemnized among persons with close biological relations. There is considerable overlap in arranged and consanguineous marriages with many cultures adopting both practices. Recent studies showed that th...

I must admit that when I first volunteered to review Consanguinity in Context, I had confused consanguinity with ex-san-guinity. Expecting a book about porphyria, rabies, and other possible sources of vam-pire myths, I was quite surprised to instead start reading about inbreeding. However, far from being disappointed, I found Alan Bit-tles' book to be extremely fascinating. Bit-tles provides an...

I must admit that when I first volunteered to review Consanguinity in Context, I had confused consanguinity with ex-san-guinity. Expecting a book about porphyria, rabies, and other possible sources of vam-pire myths, I was quite surprised to instead start reading about inbreeding. However, far from being disappointed, I found Alan Bit-tles' book to be extremely fascinating. Bit-tles provides an...

background: the frequency of pyruvate kinase (pk) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. the purpose of this study is to obtain data on the frequency and spectrum of gene mutation of pk in newborns, from shiraz and surrounding areas. materials and methods...