نتایج جستجو برای: conjugates gradient method

تعداد نتایج: 1733637  

Journal: :پژوهش های علوم و صنایع غذایی ایران 0
abdolkhalegh golkar ali nasirpour javad keramat

introduction: hydrocolloids are widely used in food systems as an emulsifying or stabilizing agent. one way to improve the emulsifying properties of hydrocolloids is complexation with proteins. in general, protein and hydrocolloid components may be combined together by either a) covalent bonding (conjugates) or b) electrostatic complexing. conjugates can be efficiently prepared during the stora...

2016
Barbara Bernardim Pedro M S D Cal Maria J Matos Bruno L Oliveira Nuria Martínez-Sáez Inês S Albuquerque Elizabeth Perkins Francisco Corzana Antonio C B Burtoloso Gonzalo Jiménez-Osés Gonçalo J L Bernardes

Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting products that undergo thiol-exchange reactions in vivo. Here we present the rational design of carbonylacrylic reagents for chemoselective cysteine bioconjugation. These reagents undergo rapid thiol Michael-addition under biocompatible conditi...

Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...

Journal: :Molecules 2018
Wenjie Jian Liangyu Wang Lanlan Wu Yuan-Ming Sun

The pulsed electric fields (PEF) treatment is a novel method for obtaining glycated proteins by way of a Maillard reaction between proteins and polysaccharides but its effect on the preparation of protein-monosaccharide conjugate has not been explored. This study aimed to prepare bovine serum albumin (BSA)-glucose and BSA-mannose conjugates using PEF in pH 10.0 at an intensity of 10 or 20 kV/cm...

2009
Fereshteh Shamsipour Amir Hassan Zarnani Roya Ghods Mahmood Chamankhah Flora Forouzesh Sedigheh Vafaei Ali Ahmad Bayat Mohammad Mehdi Akhondi Mohammad Ali Oghabian Mahmood Jeddi-Tehrani

Conjugation of monoclonal antibodies to super paramagnetic nanoparticles is an effective method for cancer diagnosis and treatment. In this study the humanized anti her2/neu monoclonal antibody- Herceptin- was conjugated to super paramagnetic iron oxide (SPIO) nanoparticles using EDC method. The concentration of the conjugated antibodies was measured by Bradford assay. The antibody-nanoparticle...

A. Golbabai, M. Mammadov , S. Seifollahi ,

A new learning strategy is proposed for training of radial basis functions (RBF) network. We apply two different local optimization methods to update the output weights in training process, the gradient method and a combination of the gradient and Newton methods. Numerical results obtained in solving nonlinear integral equations show the excellent performance of the combined gradient method in ...

2012
Ling Meng Liu Yang Xiangxuan Zhao Lucy Zhang Haizhen Zhu Chen Liu Weihong Tan

BACKGROUND Using antibody/aptamer-drug conjugates can be a promising method for decreasing toxicity, while increasing the efficiency of chemotherapy. METHODOLOGY/PRINCIPAL FINDINGS In this study, the antitumor agent Doxorubicin (Dox) was incorporated into the modified DNA aptamer TLS11a-GC, which specifically targets LH86, a human hepatocellular carcinoma cell line. Cell viability tests demon...

2004
Larry D. Bowers Peter R. Johnson

Urinary estriol measurement has been widely accepted as a useful indicator of fetoplacental status. Classically, glucuronide conjugates of estriol have been cleaved with soluble /3-glucuronidase (EC 3.2.1.31) before extraction and measurement. We have developed a system in which urine is injected directly into a “high-performance” liquid chromatograph and the conjugates are cleaved on-line in a...

Journal: :Journal of chromatography. B, Biomedical applications 1995
T B Vree E Schoondermark-van de Ven C P Verwey-van Wissen A M Bars A Swolfs P M van Galen H Amatdjais-Groenen

The following metabolites of sulfadiazine (S) were isolated from monkey urine by preparative HPLC: 5-hydroxysulfadiazine (5OH), 4-hydroxysulfadiazine (4OH) and the glucuronide (5OHgluc) and sulfate conjugate of 5OH (5OHsulf). The compounds were identified by NMR, mass and infrared spectrometry and hydrolysis by beta-glucuronidase. The analysis of S, the hydroxymetabolites (4OH, 5OH) and conjuga...

Journal: :Computational Optimization and Applications 2013

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید