We investigate the collapse of granular rodpiles as a function of particle (length/diameter) and pile (height/radius) aspect ratio. We find that, for all particle aspect ratios below 24, there exists a critical height Hl below which the pile never collapses, maintaining its initial shape as a solid, and a second height Hu above which the pile always collapses. Intermediate heights between Hl an...

BACKGROUND Knowledge of the electrophysiological substrates and the cure of atrial fibrillation (AF) is still unsatisfactory. The goal of this study was to evaluate the electrophysiological features of idiopathic AF and their relationship to the results of radiofrequency (RF) catheter ablation of AF and the safety and effectiveness of this procedure. METHODS AND RESULTS Sixteen patients with ...

UNLABELLED Although Hodgkin's lymphoma (HL) was one of the first human cancers to be cured by chemotherapy, no new agents other than brentuximab vedotin (Adcetris®, CD 30 directed antibody drug conjugate) have received US Food and Drug Administration (FDA) approval for HL since 1977. Subsets of young adult patients with HL continue to relapse, even after stem cell transplantation, warranting ne...

Despite relative success of therapy for Hodgkin's lymphoma (HL), novel therapeutic agents are needed for patients with refractory or relapsed disease. Recently, anti-PD1 immunotherapy or treatment with the anti-CD30 toxin conjugate brentuximab vedotin (BV) have been associated with remissions; however, the median responses of complete responses (CRs) with the latter were only 6.7 mo. To obtain ...

Background and aims: Health literacy (HL) can affect individual health, health communication anderror in taking medicine. The aim of this study was to determine the level of HL and associated factorsamong Iranian adults.Methods: In this cross-sectional study, 240 participants over 18 years of age referring to health centersin Hamadan, west of Iran in 2015 were selected b...

The purpose of this paper is twofold. The first is to describe some simple and robust iterative schemes for nonsymmetric and indefinite elliptic boundary value problems. The schemes are based in the Sobolev space Hl (ii) and require minimal hypotheses. The second is to develop algorithms utilizing a coarse-grid approximation. This leads to iteration matrices whose eigenvalues lie in the right h...

The mechanism of doxorubicin is compared with that of doxazolidine, a doxorubicin-formaldehyde conjugate. The IC(50) for growth inhibition of 67 human cancer cell lines, but not cardiomyocytes, is 32-fold lower with doxazolidine than with doxorubicin. Growth inhibition by doxazolidine correlates better with growth inhibition by DNA cross-linking agents than with growth inhibition by doxorubicin...

We propose a method to reduce the noise and to eliminate the effects of the inhomogeneity of the Radio-Frequency (RF) pulses and of the sensivity of the RF reception, particularly in the case of MR T-weighted images acquired with a low-field MRI system. In T-weighted images the effects of the pulse inhomogeneities vary with the tissues. Consequently the bias field is not strictly multiplicati...

Cytoplasmic male sterility (CMS) has been extensively used for hybrid seed production in many major crops. Honglian CMS (HL-CMS) is one of the three major types of CMS in rice and has contributed greatly to food security worldwide. The HL-CMS trait is associated with an aberrant chimeric mitochondrial transcript, atp6-orfH79, which causes pollen sterility and can be rescued by two nonallelic re...