Specific cell-mediated immunity (CMI) responses to rubella virus were studied in 12 children with documented congenital rubella syndrome employing a (51)Cr lymphocytotoxicity microassay. Hemagglutination inhibition antibody was detected in 11 of the 12 children, with titers ranging from 1:4 to 1:128. CMI to rubella virus was demonstrated in only 3 of the 11 antibody-positive children. The 12th ...

Acute primary maternal infection with rubella virus during pregnancy often, but not invariably, leads to the congenital rubella syndrome. Diagnosis by detection of virus specific IgM in the mother is not always possible, and in those cases in which IgM is detected the fetus has not necessarily also been infected. A method for direct, prenatal detection of fetal infection would allow more accura...

To cite: Reddy AK, Renganathan SN, Jayamohan AE, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014204204 DESCRIPTION Introduction Congenital rubella syndrome (CRS) is a spectrum of clinical findings in a patient that results from primary maternal infection with rubella virus. Diagnosis is usually made clinically but imaging findings can prompt the diagno...

= Abstract =An autopsy case of congenital rubella syndrome in a deadborn infant is reported. This case is of particular interest in view of the association of massive necrotizing encephalitis with devastation of the almost entire brain. Necrosis and calcifications were also seen in the retina and the liver. The rest of the organs showed fairly typical changes of congenital rubella syndrome, suc...

Rubella is a viral disease caused by rubella virus which affects children, young adults and women of child bearing age. It is mainly transmitted through the respiratory route. It is a major public health concern due to its potential in causing poor pregnancy outcome ranging from spontaneous abortion, stillbirth to congenital rubella syndrome (CRS). CRS is principally characterized by congenital...

Background and Aims: Rubella is predominantly a childhood disease that is endemic throughout the world and when rubella outbreaks occur, they are accompanied by birth defects following congenital rubella syndrome. Immunity to rubella virus as a teratogenic agent has an important role for prevention of these serious congenital defects. Lymphocyte proliferation assay is a way for investigation of...

Garcia, A. G. P., Olinto, F., and Fortes, T. G. 0. (1974). Archives of Disease in Childhood, 49, 181. Thymic hypoplasia due to congenital rubella. Two cases of rubella embryopathy are presented. In both, hypoplasia of the thymus and of the thymus-dependent lymphoid tissue was conspicuous. Vascular lesions identical with those described in the congenital rubella syndrome were present in the thym...

Congenital rubella syndrome (CRS) can occur in children whose mothers contract the rubella virus, sometimes called German measles, during pregnancy [2]. Depending on the gestational period when the mother contracts rubella, an infant born with CRS may be unaffected by the virus or it may have severe developmental defects. The most severe effects of the virus on fetal development occur when the ...

Congenital rubella syndrome (CRS) can occur in children whose mothers contract the rubella virus, sometimes called German measles, during pregnancy [2]. Depending on the gestational period when the mother contracts rubella, an infant born with CRS may be unaffected by the virus or it may have severe developmental defects. The most severe effects of the virus on fetal development occur when the ...