background: to determine the prevalence and characteristics of birth defects in perinatal infants in hubei province during 200l-2008. methods: the prevalence of birth defects in perinatal infants delivered after 28 weeks or more was analyzed in hubei surveillance hospitals during 200l-2008. results: the incidence of birth defects in perinatal infants from 200l to 2008 was 120.0 per 10,000 birth...

OBJECTIVES To assess the proportion and pattern of extracardiac birth defects in children with congenital heart defects referred to a tertiary care institute. METHODS Cross-sectional observational study from January 2010 to June 2011. RESULTS Out of 560 children with congenital heart defects, 98 (17.5%) had extracardiac birth defects. Fifty-six had multiple congenital defects; 36 were syndr...

the majority of coronary artery fistulas (cafs) are congenital. the anomaly accounts for 0.4% of congenital heart defects and approximately 50% of pediatric coronary vasculature anomalies. twenty percent of people with congenital cafs have other concomitant cardiac anomalies, most frequently aortic and pulmonary atresia and patent ductus arteriosus. it is worthy of note that caf with the tetral...

In patients with pulmonary hypertension associated with congenital heart defects, ultrastructural abnormalities are observed in endothelial cells, which suggest heightened metabolic function. If endothelial production of the von Willebrand factor (vWF) is increased, this may be associated with abnormal interactions with platelets leading to worsening of the pulmonary hypertension. We therefore ...

BACKGROUND Kabuki syndrome (KS) is an entity of multiple congenital malformations with mental retardation with undetermined etiology. Congenital heart defects are one of the clinical manifestations of KS with insufficient elucidations. METHODS Literature of congenital heart defects associated with KS was comprehensively retrieved, collected and reviewed. The clinical features of the congenita...

the most frequent congenital heart defects in the neonatal period are ventricular septal defects. ventricular septal aneurysms can rarely develop from an interventricular septal (ivs) defect in adults. we describe a 47-year-old man with an aneurysm in the ivs growing towards the right ventricle, which was confirmed by cardiac computed tomographic angiography and was missed by echocardiography.