In this paper, we describe the embryonic origin and patterning of the planar mosaic array of cone photoreceptor spectral subtypes in the zebrafish retina. A discussion of possible molecular mechanisms that might generate the cone mosaic array considers but discards a model that accounts for formation of neuronal mosaics in the inner retina and discusses limitations of mathematical simulations t...

In this paper, we first present a new important property for Bouligand tangent cone (contingent cone) of a star-shaped set. We then establish optimality conditions for Pareto minima and proper ideal efficiencies in nonsmooth vector optimization problems by means of Bouligand tangent cone of image set, where the objective is generalized cone convex set-valued map, in general real normed spaces.

Photoreceptor degeneration is a common cause of inherited blindness worldwide. We have identified a blind zebrafish mutant with rapid degeneration of cone photoreceptors caused by a mutation in the cone phosphodiesterase c (pde6c) gene, a key regulatory component in cone phototransduction. Some rods also degenerate, primarily in areas with a low density of rods. Rod photoreceptors in areas of t...

PURPOSE To describe the electrophysiological, histologic, and hereditary features of a naturally occurring rat model of cone function loss. METHODS Dark- and light-adapted electroretinograms (ERGs) were used to evaluate retinal function. The thickness and architecture of the retina were observed by light microscopy. The cone density was investigated by wholemount immunocytochemistry. The inhe...

We construct the covariant κ-symmetric superstring action for type IIB superstring on plane wave space supported by Ramond-Ramond background. The action is defined as a 2d sigma-model on the coset superspace. We fix the fermionic and bosonic light-cone gauges in the covariant Green-Schwarz superstring action and find the light-cone string Lagrangian and the Hamiltonian. The resulting light-cone...

This paper develops slacks-based measure (SBM) and additive SBM (ASBM) to evaluate efficiency of decision making units (DMUs) in a two-stage structure with undesirable outputs and feedback variables from the internal perspective. The SBM model is linearized  for a specific weight and the ASBM model is reformulated as a second order cone program. The target values for all inputs, outputs (both d...

Cone phototransduction and survival of cones in the human macula is essential for color vision and for visual acuity. Progressive cone degeneration in age-related macular degeneration, Stargardt disease, and recessive cone dystrophies is a major cause of blindness. Thyroid hormone (TH) signaling, which regulates cell proliferation, differentiation, and apoptosis, plays a central role in cone op...

Purpose Blue cone monochromacy (BCM) is an X-linked congenital vision disorder characterized by complete loss or severely reduced L- and M-cone function. Patients with BCM display poor visual acuity, severely impaired color discrimination, myopia, nystagmus, and minimally detectable cone-mediated electroretinogram. Recent studies of patients with BCM with adaptive optics scanning laser ophthalm...

Draft tube of Francis type hydraulic turbine usually consists of: cone, elbow and diffuser. On the contrary, in some power stations an extra pipe should be added to the draft tube at the bottom of cone because of installation limitation. In this paper, this special case has been numerically studied. To this end CFD analysis was applied to simulate all parts of hydraulic turbine. A homogeneous m...