Two-thirds partial hepatectomy (PH) induces differentiated cells in the liver remnant to proliferate and regenerate to its original size. The proliferation-specific HNF-3/fork head homolog-11B protein (HFH-11B; also known as Trident and Win) is a family member of the winged helix/fork head transcription factors and in regenerating liver its expression is reactivated prior to hepatocyte entry in...

Glucocorticoid excess increases fat mass, preferentially within omental depots; yet circulating cortisol concentrations are normal in most patients with metabolic syndrome (MS). At a pre-receptor level, 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) activates cortisol from cortisone locally within adipose tissue, and inhibition of 11b-HSD1 in liver and adipose tissue has been proposed as a ...

The 11B(3He, t), 11B(d, d), and 11B(p, p) reactions were measured at forward scattering angles including 0 to study the isovector and isoscalar spin-flip M1 strengths in 11B. The measured 11B(3He, t) cross sections were compared with the results of the distorted-wave impulseapproximation (DWIA) calculation, and the Gamow-Teller (GT) strengths for low-lying states in 11C were determined. The GT ...

Quaternary ammonium benzocycloheptene compound 1 has previously been reported as a clinical candidate for an injectable CCR5 antagonist. In order to develop an orally active CCR5 antagonist, derivatives of tertiary amine benzocycloheptene 2, the chemical precursor to 1, were investigated. The benzocycloheptene ring was converted to benzothiepine and benzazepine rings and it was found that these...

2014 The cross-sections and resolving powers of the 11B(p, p’) inelastic scattering at Ep = 30.3 MeV are analyzed in the coupled-channels formalism. These calculations suggest a positive value for the quadrupole deformation 03B22 of 11B (prolate) and give the result 03B22 = + 0.52. LE JOURNAL DE PHYSIQUE LETTRES Classification Physics Abstracts 4.370 TOME 37, AVRIL 1976, In the understanding of...

The chelating aluminum complex [2-(Me2NCH2)C2B10H10]AlX2 (X = Br 3, CH3 4) was synthesized using 2-dimethylaminomethyl-o-carboranyl lithium (LiCabN, 2) with tribromide (AlBr3) or dimethylaluminum bromide (Me2AlBr), resulting in a modest yield. Compound 4 obtained by reacting compound 3 methyllithium (CH3Li) toluene. All compounds were characterized infrared (IR) spectroscopy; 1H, 11B, 13C nucle...

Vancomycin-resistant Staphylococcus aureus VRSA-10 was isolated in 2009, whereas VRSA-11A and VRSA-11B were isolated from the same patient in 2010. Growth curves and determination of the nature of the peptidoglycan precursors and of the VanX d,d-dipeptidase activity in the absence and in the presence of vancomycin indicated that vancomycin resistance was inducible in VRSA-10, that VRSA-11A was ...

11Beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) locally amplifies active glucocorticoids within specific tissues including in brain. In the hippocampus, 11b-HSD1 messenger RNA increases with aging. Here, we report significantly greater increases in intrahippocampal corticosterone (CORT) levels in aged wild-type (WT) mice during the acquisition and retrieval trials in a Y-maze than age-mat...

A series of 2-phenyl-benzopyranopyrimidine (PBPP) derivatives with alkylamino side chains were synthesized and found to be a new type of highly selective ligand to bind with telomeric G-quadruplex DNA, and their biological properties were reported for the first time. Their interactions with telomeric G-quadruplex DNA were studied with FRET melting, surface plasmon resonance, CD spectroscopy, an...

Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis. Glucocorticoid pharmacotherapy reduces mast cell number, maturation and activation but effects at physiological levels are unknown. Within cells, glucocorticoid concentration is modulated by the 11b-hydroxysteroid dehydrogenases (1...