Compartmental modeling is a widely used tool in neurophysiology but the detail and scope of such models is frequently limited by lack of computational resources. Here we implement compartmental modeling on low cost Graphical Processing Units (GPUs), which significantly increases simulation speed compared to NEURON. Testing two methods for solving the current diffusion equation system revealed w...

This paper describes a framework, called QCMF (Qualitative Compartmental Modeling Framework), which assists the user in formulating models of a physical system and in analyzing their behaviors through the simulation of the effects of a variety of different perturbations of the system. QCMF has adopted the compartmental theory as modeling ontology: a system is represented as a finite set of inte...

Compartmental models provide a major source of insight into the information processing functions of single neurons. Over the past 15 years, one of the most widely used neuronal morphologies has been the cell called "j4," a layer 5 pyramidal cell from cat visual cortex originally described in Douglas, Martin, and Whitteridge (1991). The cell has since appeared in at least 28 published compartmen...

Introduction Compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. Biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. In this study, we aimed to develop a pharmacokinetic model of 153Sm-maltolate complex as a novel therapeutic agent and...

To guide the collection of data under emergent epidemic conditions, we reviewed compartmental models of historical Ebola outbreaks to determine their implications and limitations. We identified future modeling directions and propose that the minimal epidemiologic dataset for Ebola model construction comprises duration of incubation period and symptomatic period, distribution of secondary cases ...

This paper describes a general approach to the compartmental modeling of nuclear data based on spectral analysis and statistical optimization. We utilize the renal physiology as test case and validate the method against both synthetic data and real measurements acquired during two micro-PET experiments with murine models.

Examples of Aggregate (Compartmental) Simulation Models 19 SimSmoke 19 University of Michigan Tobacco Prevalence and Health Effects Model 23 Tobacco Policy Model 24 Benefits of Smoking Cessation Outcome 25 Smoking-Attributable Morbidity, Mortality, and Economic Costs 25 Cancer Strategy Analysis and Validation Effect 26 Cancer Intervention and Surveillance Modeling Network (CISNET) 26 Examples o...