نتایج جستجو برای: comparative proteomics

تعداد نتایج: 274279  

Journal: :genetics in the 3rd millennium 0
mahmood maleki elahe fatemi booshehry mojtaba mortazavi

proteomics has emerged since 1995 for studying the total proteome of cells, tissues, or organisms at any condition. the study of proteins has a fundamental importance because they are the functional and final molecules of the gene expression process and proteomics could be a valuable technique for achieving this purpose. mass spectrometry is a complementary technique for proteomics that allows ...

2013
Barbara Deracinois Christophe Flahaut Sophie Duban-Deweer Yannis Karamanos

Proteomics became a key tool for the study of biological systems. The comparison between two different physiological states allows unravelling the cellular and molecular mechanisms involved in a biological process. Proteomics can confirm the presence of proteins suggested by their mRNA content and provides a direct measure of the quantity present in a cell. Global and targeted proteomics strate...

Journal: :hepatitis monthly 0
jamal sarvari department of bacteriology and virology, school of medicine, shiraz university of medical sciences, shiraz, ir iran zahra mojtahedi institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, ir iran yasuhiro kuramitsu department of biochemistry and functional proteomics, yamaguchi university graduate school of medicine, yamaguchi, japan mohammad reza fattahi department of internal medicine, school of medicine, shiraz university of medical sciences, shiraz, ir iran abbas ghaderi institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, ir iran kazuyuki nakamura department of biochemistry and functional proteomics, yamaguchi university graduate school of medicine, yamaguchi, japan

background hepatocellular carcinoma (hcc), a major fatal cancer worldwide, is induced by different etiological factors in the liver. objectives to gain insight into serum protein profiling of hcc with different etiologies. patients and methods we subjected the sera of hbv-hcc, hcv-hcc, non-b non-c-hcc patients, and healthy volunteers to two-dimensional gel electrophoresis (2-de) and liquid chro...

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...

Journal: :Trans. Large-Scale Data- and Knowledge-Centered Systems 2011
Paola Bonfante Francesca Cordero Stefano Ghignone Dino Ienco Luisa Lanfranco Giorgio Leonardi Rosa Meo Stefania Montani Luca Roversi Alessia Visconti

The beginning of post-genomic era is characterized by a rising numbers of public collected genomes. The evolutionary relationship among these genomes may be caught by means of the comparative analysis of sequences, in order to identify both homologous and non-coding functional elements. In this paper we report on the on-going BIOBITS project. It is focused on studies concerning the bacterial en...

Objective(s): Resistance to medications is one of the main complications in chemotherapy of cancer. It has been shown that some multidrug resistant cancer cells indicate more sensitivity against cytotoxic effects of TNF-α compared to their parental cells. Our previous findings indicated vulnerability of the mitoxantrone-resistant breast cancer cells MCF-7/MX to cell de...

2002
Gary Hardiman

2002 © Ashley Publications Ltd Genomics and proteomics are playing increasingly important roles as discovery tools in basic biological sciences and as diagnostic and rational therapeutic aids in the clinical arena. In recent years, high-density arrays of specified DNA sequences have gained popularity. Protein microarrays are at the forefront of this biochip revolution and promise the parallel e...

2017
Daxing Cai Yang Li Chunlei Zhou Yulin Jiang Jian Jiao Lin Wu

Primary cutaneous amyloidosis (PCA) is a localized skin disorder that is characterized by the abnormal deposition of amyloid in the extracellular matrix (ECM) of the dermis. The pathogenesis of PCA is poorly understood. The objective of the present study was to survey proteome changes in PCA lesions in order to gain insight into the molecular basis and pathogenesis of PCA. Total protein from PC...

Journal: :The Journal of Cell Biology 2006
Georg H.H. Borner Michael Harbour Svenja Hester Kathryn S. Lilley Margaret S. Robinson

Clathrin-coated vesicles (CCVs) facilitate the transport of cargo between the trans-Golgi network, endosomes, and the plasma membrane. This study presents the first comparative proteomics investigation of CCVs. A CCV-enriched fraction was isolated from HeLa cells and a "mock CCV" fraction from clathrin-depleted cells. We used a combination of 2D difference gel electrophoresis and isobaric tags ...

Journal: :journal of paramedical sciences 0
seyed hassan moghaddamnia faculty of paramedical sciences, shahid beheshti university of medical sciences

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