Purpose: This paper aims to examine the suitability of a social enterprise model for community health promotion organisations working in disadvantaged neighbourhoods. It focuses on organisational culture, social resources and capacity as pre-requisites for entrepreneurial activities. Design/methodology/approach: This paper is based on ethnographic case studies in England including semi-structur...

The field of pharmaceutical modelling has, in recent years, benefited from using probabilistic methods based on cellular automata, which seek to overcome some of the limitations of differential equation based models. By modelling discrete structural element interactions instead, these are able to provide data quality adequate for the early design phases in drug modelling. In relevant literature...

UNLABELLED Interactions between proteins and DNA molecules lie at the core of the fundamental cellular processes such as transcriptional regulation. Some of these interactions have been experimentally described at atomic scale, but the molecular details of many others remain to be discovered. TFmodeller exploits the current knowledge about protein-DNA interfaces contained in the Protein Data Ba...

The conceptual spaces approach has emerged as a new and powerful way of thinking about concepts. In earlier work, the present authors have addressed the question of how to model vague concepts in the conceptual spaces framework. That in turn was instrumental in Decock’s and Douven’s account of a graded membership relation in further work. In this paper, we make use of the account of graded memb...

This paper presents an accurate and efficient computational strategy for the simulation of coupled masonry structures which combines a partitioned mesoscale modelling approach for brick-masonry components with a mortar mesh tying method for non-conforming interfaces. This allows the independent modelling of the individual structural components and the efficient tying of the subdomains with accu...

Geno3D (http://geno3d-pbil.ibcp.fr) is an automatic web server for protein molecular modelling. Starting with a query protein sequence, the server performs the homology modelling in six successive steps: (i) identify homologous proteins with known 3D structures by using PSI-BLAST; (ii) provide the user all potential templates through a very convenient user interface for target selection; (iii) ...

The enormous increase in data availability brought about by genomic projects is paralleled by an equally unprecedented increase in the expectations for new medical, pharmacological, environmental and biotechnological discoveries. Whether or not we will be able to meet (at least partially) these expectations will depend on how well we will be able to interpret the data and translate the mono-dim...

This paper aims to compare the descriptive and predictive power of two classes of statistical estimation models for multimodal network flows, viz. the logit model and the neural network model. The application concerns a large data set on inter-regional European freight flows for two commodity categories (food and chemicals). After an exposition of policy issues, methodological and modelling que...