First, outcome variable of “duration of comatose state” included all patients irrespective of their survival status. Failure to censor this time-to-event ‘duration of coma’ variable by mortality in this study is a major methodological flaw in evaluating treatment efficacy. Indeed, more aptly definable endpoint would be the “duration of resolution of abnormal mental status (or length of time to ...

Background—Management of acute type A aortic dissection (AADA) complicated by coma remains controversial. We analyzed our experience in managing AADA complicated by coma to determine the relationship of duration of preoperative coma to postoperative neurological recovery. Methods and Results—Between September 2003 and October 2010, 181 patients with AADA were treated, including 27 presenting wi...

Tiagabine is an anticonvulsant acting by selective inhibition of neuronal and glial gamma-aminobutyric acid uptake, resulting in increased gamma-aminobutyric acid-mediated inhibition in the brain. Few reports in the literature describe the clinical course of severe tiagabine intoxication. A 44-year-old woman presented after deliberate self-poisoning with 100 tiagabine 15 mg tablets (1,500 mg; 2...

The effect of severe insulin-induced hypoglycemia on the activity of the pyruvate dehydrogenase enzyme complex (PDHC) was investigated in homogenates of frozen rat cerebral cortex during burst suppression EEG, after 10, 30, and 60 min of isoelectric EEG, and after 30 and 180 min and 24 h of recovery following 30 min of hypoglycemic coma. Changes in PDHC activity were correlated to levels of lab...

Objective: To find out efficacy and benefits of early intervention of coma arousal therapy on coma patients after sustaining traumatic head injury. Materials and methods: Thirty comatose patients with traumatic head injury were systematic randomly selected. Both experimental group and control group were having 15 patients each. Patients in experimental group were given coma arousal therapy whil...