BACKGROUND The transmembrane receptor guanylate cyclase-C (GCC) has been found to be expressed in colorectal cancers. However, limited data are available on GCC protein expression in non-colorectal gastrointestinal tumors and few studies have reported whether GCC protein expression was consistently preserved in synchronous primary and metastatic cancer tissues. METHODS GCC protein status was ...

Objectives:The aim of the study is to determine the histopathological features of primary colorectal cancers. Materials and methods: 102 patients with primary colorectal tumors diagnosed over a 5 year period studied histopathologically they were classified using the WHO classification of colorectal malignancies. primary gastrointestinal tumors Diagnosis. Result: Most of the colorectal tumors we...

Genomic instability and epigenetic aberrations are important classifiers of human tumors, yet, their interrelations are poorly understood. We used Lynch syndrome (LS) to address such relationships. Forty-five tumors (11 colorectal adenomas, 18 colorectal carcinomas, and 16 ovarian carcinomas) were profiled for CpG Island Methylator Phenotype (CIMP) and somatic mutations. All tumors showed high-...

background: mucinous adenocarcinoma colorectal cancer present at a more colorectal advanced stage of disease and showe a poorer prognosis than those with other types of carcinoma. the purpose of the present study was to clarify the clinicopathological characteristics of mucinous colorectal carcinoma in the iranian population. methods: 110 patients with mucinous adenocarcinoma were selected from...

Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical resection of a primary colorectal cancer. In this study we examined the characteristics of women with colorectal cancer for whom synchronous oophorectomy had been performed. In this cross-sectional study, records of patients with colorectal cancer from April 1991 through October 1999 who had undergone surgery for ...

Microsatellite instability (MSI) is a well-recognized phenomenon that is classically a feature of tumors in the hereditary non-polyposis colorectal syndrome. Ten to 15% of sporadic colorectal cancers, however, will have MSI. Microsatellite unstable tumors can be divided into two distinct MSI phenotypes: MSI-high (MSI-H) and MSI-low (MSI-L). MSI sporadic colorectal cancers with a high level of M...

HYPOTHESIS Stage I or II colorectal carcinomas with microsatellite instability (MSI) are characterized by more isolated lymph nodes in the resected specimen than their counterparts with microsatellite stability (MSS). DESIGN Prospective study. SETTING Academic research. PATIENTS Using a pentaplex polymerase chain reaction assay, MSI status was determined prospectively for 135 operative pa...

BACKGROUND Although colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain undefined. GUCY2C has emerged as an intestine-specific tumor suppressor controlling epithelial homeostasis through circuits canonically disrupted in cancer. Surprisingly, the GUCY2C tumor...

BACKGROUND The development of noninvasive screening tests is important to reduce mortality from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA methylation from exfoliated cancer cells in feces. METHODS We first analyzed methylation of the RASSF2 and SFRP2 gene promoters from 788 primary gastric and colorectal tissue specimens to determine whether methylation p...

Benign neoplasms of the colon, rectum, anus and anal canal are true neoplasia colon mucosa associated with a high risk colorectal cancer (CC). The literature review analyzes epidemiology, factors, modern methods diagnosis treatment, describes priority minimally invasive interventions for benign tumors.