The cellular mechanism for Cl(-) and K(+) secretion in the colonic epithelium requires K(+) channels in the basolateral and apical membranes. Colonic mucosa from guinea pig and rat were fixed, sectioned, and then probed with antibodies to the K(+) channel proteins K(V)LQT1 (Kcnq1) and minK-related peptide 2 (MiRP2, Kcne3). Immunofluorescence labeling for Kcnq1 was most prominent in the lateral ...

Santos, Javier, Paul R. Saunders, Nico P. M. Hanssen, Ping-Chang Yang, Derrick Yates, Jack A. Groot, and Mary H. Perdue. Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G391– G399, 1999.—We examined the effect of stress on colonic epithelial physiology, the role of corticotropin-releasing...

Wang, Timothy C., and Graham J. Dockray. Lessons From Genetically Engineered Animal Models. I. Physiological studies with gastrin in transgenic mice. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G6–G11, 1999.—The role of gastrin in the regulation of gastrointestinal growth and acid secretion has been addressed through recent studies involving transgenic and knockout mice. The role of ...

cies in women and the main cause of cancer-related deaths (1). Breast cancer usually metastasizes to the lymph nodes, lung, bone, liver or brain. However, metastases to the gastrointestinal (GI) tract are rare. The most frequent sites of the GI tract involved are the stomach and the small intestine, while a colonic metastases is extremely rare (2, 3). Because of its rarity and its nonspecific c...

Correlation in mortality data between breast cancer and colonic cancer, and increased incidence of colonic cancer in women with breast cancer suggest common factors in their etiology. Similarly protective effect of increasing parity from colonic cancer, and relatively better prognosis in women may imply a common role for sex steroid hormones. In this study clinicopathologic parameters as well a...

case presentation we report a case of idiopathic colonic varices, diagnosed at a routine colonoscopy performed for nespecific abdominal disturbances in a female patient without liver disease or pancreatic conditions responsible for portal hypertension development. conclusions the development of colonic varices in the absence of a certain trigger represents a major issue for practitioners due to...

Colonic mucosal Schwann cell hamartoma is an extremely rare entity, presenting as small colonic polyp, associating with no clinical symptoms and harboring no clinical significance. However, its mimics, such as GI neurofibroma/neurofibromatosis, ganglioneuroma, etc. are possible GI manifestations of hereditary syndromes and therefore are integral part of the patient workup and disease diagnosis....

Proctectomy followed by straight coloanal anastomosis (CAA) often results in poor functional outcome known as the anterior resection syndrome. It is now based on evidence that a colonic J-pouch CAA improves outcome in the first 2 years. We assessed the very late functional outcome of CAA patients with or without a pouch. These results show that the functional benefit of the J-pouch anastomoses ...

Zhu, Yingting, Ping Hua, Shazia Rafiq, Eric J. Waffner, Michael E. Duffey, and Peter Lance. Ca2 and PKCdependent stimulation of PGE2 synthesis by deoxycholic acid in human colonic fibroblasts. Am J Physiol Gastrointest Liver Physiol 283: G503–G510, 2002. First published May 1, 2002; 10.1152/ajpgi.00525.2001.—We investigated prostanoid biogenesis by human colonic fibroblasts (CCD-18Co cells and ...

The treatment strategy of colonic injuries is a debatable and highly controversial subject worldwide in various medical centers. The method of treatment of left and .. right colonic injuries, diversity or similarity in their management and particularly differences between the treatment of war-associated injury from other types of colonic damage are among the unsettled issues. The present s...