Combined Bisulfite Restriction Analysis (COBRA) quantifies DNA methylation at a specific locus. It does so via digestion of PCR amplicons produced from bisulfite-treated DNA, using a restriction enzyme that contains a cytosine within its recognition sequence, such as TaqI. Here, we introduce COBRA-seq, a genome wide reduced methylome method that requires minimal DNA input (0.1-1.0 mg) and can e...

during the journey to India. I have now received specimens of the serum on two occasions, and find that they possess a well-marked power of neutralising cobra venom, the last received specimens being especially active. I do not propose on the present occasion to go into the details of my experiments. I may, however, briefly mention a semi-practical application that I have been able to make of P...

The purpose of this paper is to introduce Cobra, an econometric software package designed for CO-BReaking Analysis. Cobra is programmed in Ox, see Doornik (2002), and consists of three modules: Firstly, the CobraDgp module is a class derived from the Database class and enables the user to generate a multivariate time series that is subject to multiple breaks in its intercept as well as linear t...

The neutralizing capacity of antivenom prepared against Thai cobra (Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 LD50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using N. kaouthia ve...

Initial reports about the new COBRA premium subsidy program for recently laid-off workers indicate that enrollment in COBRA continuation coverage has increased substantially, with a healthier mix of individuals enrolling than before. Moreover, implementation has gone smoothly, and most eligible people have heard about the subsidy. Still, many of those who are eligible cannot afford to purchase ...