abstract aim: to assess anti-neuronal antibodies (na) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (cd) patients. background: neurological manifestations are estimated to occur in about 10% of celiac disease patients and na to central nervous system (cns) and enteric nervous system (ens) are found in a significant proportion of them. little is ...

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

A Central nervous system (CNS) hemorrhage is bleeding in or around the brain and spinal cord. Reasons of CNS hemorrhage include high blood pressure, cancers, drug abuse, abnormally weak blood vessels that leakage, and trauma. Regression of CNS bleeding was confirmed to be relatively repetitive in patients with severe FV, FX, FVII and FXIII deficiencies. Generally in CNS hemorrhage, radiological...

the cannabinoidergic system acquired a reputation as the most abundant g-protein coupled receptor in the cns that acts as retrograde modulator of neurotransmitter release. recently, endocannabinoids (ecbs) have been highlighted as neurodevelopmental signaling cues that exert a regulatory role in brain development. the interruption in ecb system elements (including receptors and enzymes of synth...

We have previously reported that imatinib, a c-Abl inhibitor, reduces caveolae-mediated endocytosis of endothelial cells and inhibits the extravasation IgG in steady state. However, target signaling pathway behind this mechanism remains unclear. Here, we established an vitro culture system using human dermal microvascular (HDMEC) to mimic IgG. Thrombin histamine increased translocation through ...

The protective blood-brain barrier normally allows diffusion of small molecules such as oxygen and carbon dioxide, and transport of essential nutrients, but excludes large proteins and other blood constituents from the interstitial space of the CNS. However, head trauma, stroke, status epilepticus and other pathological conditions can all compromise the integrity of this barrier, and allow bloo...

Emerging evidence demonstrates that thrombin exerts physiological and pathological functions in the central nervous system. Both prothrombin and its active form thrombin have been detected locally in the brain. The cellular functions of thrombin are mainly regulated by G protein-coupled protease-activated receptors (PARs). Thrombin can signal via PAR-1, PAR-3 and PAR-4. Some neurological diseas...

Glutamate is extensively and relatively uniformly distributed in the central nervous system (CNS) and its effects mediated by two distinct groups of receptors including Ionotropic and metabotropic glutamate receptors. Concentration of glutamate in the nervous system is much higher than in other tissues. Glutamate receptors play an important role in synaptic transmission, neural plasticity and n...

Objective: The purpose of this study was to express and purify recombinant anti-thrombin in Saccharomyces cerevisiae BY4741 expression system. Methods: cDNA of human anti-thrombin gene was amplified with specific primers and cloned into pYES2/CT vector with His-tag for easier purification using Ni2+ Results: Protein was purified to homogeneity and was confirmed as anti-thrombin, using SDS-PAGE ...