In this paper, a new topology that is a symmetric five bar profile for displacement amplification is proposed, and a compliant mechanical amplifier (CMA) based on the new topology is designed to amplify the stroke of a piezoelectric actuator. The new CMA can convert the motion generated by a PZT actuator with a large amplification ratio (24.4) in a very compact size, and it has a high natural f...

Collismycin A (CMA), a microbial product, has anti-proliferative activity against cancer cells, but the mechanism of its action remains unknown. Here, we report the identification of the molecular target of CMA by ChemProteoBase, a proteome-based approach for drug target identification. ChemProteoBase profiling showed that CMA is closely clustered with di-2-pyridylketone 4,4-dimethyl-3-thiosemi...

Equalization plays an important role for the communication system receiver to correctly recover the symbol send by the transmitter, where the received signals may contain additive noise and intersymbol interference (ISI). Blind equalization is a technique of many equalization techniques at which the transmitted symbols over a communication channel can be recovered without the aid of training se...

Oxidatively damaged proteins accumulate with age in almost all cell types and tissues. The activity of chaperonemediated autophagy (CMA), a selective pathway for the degradation of cytosolic proteins in lysosomes, decreases with age. We have analyzed the possible participation of CMA in the removal of oxidized proteins in rat liver and cultured mouse fibroblasts. Added to the fact that CMA subs...

This report proposes a simple modification of the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) for high dimensional objective functions, that reduces the internal time and space complexity from quadratic to linear. The covariance matrix is constrained to be diagonal and the resulting algorithm, sep-CMA-ES, samples each coordinate independently. Because the model complexity is reduce...

Pseudomonas syringae pv. tomato DC3000 produces the phytotoxin coronatine, a major determinant of the leaf chlorosis associated with DC3000 pathogenesis. The DC3000 PSPTO4723 (cmaL) gene is located in a genomic region encoding type III effectors; however, it promotes chlorosis in the model plant Nicotiana benthamiana in a manner independent of type III secretion. Coronatine is produced by the l...

Adaptive blind equalization has gained widespread use in communication systems that operate without training signals. In particular, the Constant Modulus Algorithm (CMA) has become a favorite of practitioners due to its LMS-like complexity and desirable robustness properties. The desire for further reduction in computational complexity has motivated signed-error versions of CMA, which have been...

In a group of Thai patients with P. falciparum acute malaria, circulating malarial antigens (CMA) were detected in 27/33 cerebral malaria (CM) cases and 31/43 noncerebral cases. Delayed cutaneous responses to phytohemagglutinin and candidin were found frequently negative in patients with CMA, especially in the CM group. Mean in vitro lymphocyte proliferative responses to lectins were lower in t...

We compare some blind finite-impulse-response (FIR) equalisation schemes for high-order quadrature amplitude modulation (QAM) signalling. The popular constant modulus algorithm (CMA) is used as a benchmark in an investigation of two blind FIR equalisers, namely, a bootstrap maximum a posteriori probability (MAP) equaliser and a recently introduced concurrent CMA and decision directed (DD) equal...

BACKGROUND Cow's milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called "allergic march". We aimed to detect genetic associations of CMA using reported single nucleotide polymorphisms (SNP) in other allergic diseases and genetic mutations within the fil...