Penicillin- (cloxacillin-) resistant mutants of Bacillus subtilis were isolated in a stepwise fashion and the five penicillin-binding components (PBCs) in each were examined to determine which of the proteins, if any, corresponds to the penicillin killing site. PBCs II and V were previously eliminated as the likely penicillin targett. In the present work, PBC IV showed no change in sensitivity ...

We compared the efficacy of ceftriaxone combined with gentamicin, both given once a day, with that of cloxacillin given every 4 h plus gentamicin given once a day or in three daily doses (t.i.d.) for the treatment of experimental methicillin-susceptible staphylococcal endocarditis. The antibiotics were administered by using human-like (H-L) pharmacokinetics that simulated the profiles of these ...

Comparative allometric analysis of selected pharmacokinetic parameters of cloxacillin, dicloxacillin and flucloxacillin in four animal species (cats, dogs, pigs and sheep) was performed. The correlations between the total body clearance (CLB) and the volume of distribution (Vdarea) to the body weight of animals were established. They can be expressed by the equations: cloxacillin − CLB =5.68W ,...

Two hundred and thirty-seven selected, penicillin-resistant isolates of Staph. aureus collected over a 13-month period were examined retrospectively for cloxacillin/methicillin resistance; 44 were found to be resistant. Six other strains which had been preserved from an earlier period were also found to be resistant. All 50 cloxacillin-resistant strains were in addition resistant to streptomyci...

In recent years, the emergence of Staphylococcus aureus strains with reduced susceptibility to glycopeptides has raised considerable concern. We studied the efficacy of vancomycin and teicoplanin, as well as cloxacillin and cefotaxime, against the infection caused by four S. aureus strains with different glycopeptide and beta-lactam susceptibilities (strains A, B, C, and D; MICs for vancomycin ...