UNLABELLED We used quantitative topographical electroencephalography (EEG) to determine the time course of changes in brain electrical activity after clonidine infusion. Twenty healthy male volunteers (aged 24 +/- 5 yr) were included in the randomized, double-blind, placebo-controlled (Group 1, placebo, n = 10; Group 2, 2.0 micrograms/kg clonidine, n = 10) study. EEG (17 electrodes, common aver...

Spinal alpha-2 adrenoceptors and cholinergic receptors are involved in the regulation of acute nociception and the facilitated processing. The aim of this study was to examine the pharmacological effect of an intrathecal alpha-2 agonist and a cholinesterase inhibitor on the facilitated pain model induced by formalin injection and to determine the nature of drug interaction using an isobolograph...

Clonidine has been used off-label in children and adolescents with attention deficit and hyperactivity disorders (ADHD) with or without comorbidities. Clonidine extended-release was recently approved by the US Food and Drug Administration for ADHD in children. This review evaluates the efficacy and safety of clonidine extended-release and clonidine in children and adolescents with ADHD. A searc...

Stressful stimuli, electric footshock (FS), immobilized-water immersion (IW), and cold-water swimming (CWS), produced analgesia and prolonged the pentobarbital hypnosis as well as morphine and clonidine. Naloxone completely antagonized the analgesic effects of morphine and FS and partially that of IW; however, that of clonidine and CWS were not reversed by naloxone. Naloxone eliminated the hypn...

BACKGROUND Inhibition of cardiac sympathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic alpha2-adrenoceptors is the most widely accepted mechanism of action of the antisympathetic drug clonidine; however, other target proteins have been postulated to contribute ...

  Purpose: Today considerable advances have been achieved in application of nano-particles.   Fullerene is one of the artificial forms of carbon element. Long life cycle of medicines in the   human body is a success factor in delivery of medicine to the specific place. Lots of nanoparticles   are being developed in this field and from a medical point of view, achieving such   goals is vital. Th...

The aim of this study was to evaluate the efficacy, potency and side effects of clonidine as compared to tramadol in post spinal anaesthesia shivering. In this double blind comparative study, 90 American Society Anaesthesiologists grade I & II patients aged between 18-35 years scheduled for elective LSCS under spinal anaesthesia who subsequently developed shivering intra operatively were select...

BACKGROUND AND AIMS Laryngoscopy and endotracheal intubation are associated with reflex sympathetic stimulation, known as pressor response and can cause major complications. We compared the attenuating effect of time-tested lignocaine versus clonidine on the hemodynamic response to laryngoscopy and intubation in neurosurgical cases. DESIGN A prospective, randomized, comparative, double-blind ...

The use of dexmedetomidine with concurrent scalp block is increasingly being utilized as an effective and safe anesthetic approach for awake craniotomy (AC). Dexmedetomidine alpha-2 adrenergic receptor (α2-AR) agonist dose-dependent sedative, analgesic, anxiolytic properties while preserving respiratory function. challenge the arises when patient has a clonidine allergy, which also α2-AR agonis...