background & importance: primary hemifacial spasm is usually caused by microvascular compression of the facial nerve at its root exit zone at brainstem without any space-occupying pathology. secondary or so-called symptomatic hemifacial spasm has an additional underlying pathology e.g. tumors leading to the microvascular compression. we review and discuss the pathophysiology and the literature ...

Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) have been detected in patients presenting with seizures in the first few months of life and Rett syndrome features. Twenty-seven cases have been detected to date. Generalized intractable seizures, as infantile spasms, and generalized tonic-clonic seizures and myoclonic seizures characterize the clinical picture of CDKL5 mutat...

BACKGROUND Hemifacial spasm (HFS) is a movement disorder characterized by intermittent, involuntary clonic or tonic-clonic contractions of muscles innervated by the ipsilateral facial nerve. Recent studies have documented change in quality of life after HFS management with botulinum toxin injection. However, we failed to locate any study that documented change in quality of life after surgical ...

the anticonvulsant activity of astragalus squarrosus total extract was assessed in pentylenetetrazole (ptz)-induced convulsion in mice, with diazepam as the standard drug, while mechanistic studies were also conducted using flumazenil, a gaba a-benzodiazepine receptor complex site antagonist. the extract produced protection against convulsion at 400 mg/kg, comparable with protection of benzodia...

dobutamine stress echocardiography (dse) has been widely used as a diagnostic and prognostic modality in the management of stress. dse is associated with limited complications and adverse effects on the health of patients. in this case report, we described a 42-year-old female patient with dobutamine-induced coronary artery spasm with history of exertional dyspnea, which had deteriorated recent...

BACKGROUND We reported less provoked spasm in the left circumflex artery (LCX) by acetylcholine testing compared with the left anterior descending artery (LAD) and right coronary artery (RCA), so we investigated the clinical characteristics of provoked spasm in the LCX by ergonovine (ER) testing.Methods and Results:We retrospectively analyzed 1,185 consecutive cases of intracoronary ER testing ...

objective: infantile spasm is an age dependent ant myoclonic seizure which occurs in 25 per 100,000 live births. we aimed to investigate effect of intravenous methypredinsolone pulse on the infantile spasm in patients hospitalized in 17 shahrivar hospital, rasht. materials and methods: this is an observational case series which was conducted on 20 infants with infantile spasms hospitalized in 1...

INTRODUCTION We report an unusual case of facial pain and swelling caused by compression of the facial and vestibulocochlear cranial nerves due to the tortuous course of a branch of the posterior inferior cerebellar artery. Although anterior inferior cerebellar artery compression has been well documented in the literature, compression caused by the posterior inferior cerebellar artery is rare. ...

BACKGROUND Radial artery spasm is a common hinderance during transradial approaches for neuroangiography. Ways of alleviation have been described, including patient sedation, local lidocaine, or even prophylactic administration intra‐arterial vasodilators. METHODS We present case wedged catheter attributable to radial spasm, which failed all conventional methods relieve spasm. RESULTS The was u...