The effects of hypoxia on susceptibility to pentylenetetrazol (PTZ)-induced seizures were assessed in juvenile rats. Animals at postnatal (P) day 25 were exposed to hypobaric hypoxia (simulated altitude of 7000 m) for 8 h PTZ in a dose of 100 mg/kg was injected 1, 3 or 7 days later and latency, pattern and severity of seizures were registered. Mortality due to seizures was also evaluated. Two s...

During a police chase on foot, a previously well police officer was hit mistakenly by a taser shot meant for the suspect. The taser gun had been fired once, sending 2 barbed darts into his upper back and occiput. Within seconds, the officer collapsed and experienced a generalized tonic-clonic seizure with loss of consciousness and postictal confusion. Subsequent magnetic resonance imaging scans...

Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure. ...

OBJECTIVE To study the clinical features and genetics of idiopathic generalised epilepsy (IGE) beginning in adult life. METHODS Consecutive patients with IGE, defined as generalised seizures with spike or polyspike and wave on EEG, were studied in the setting of a first seizure clinic where an early postictal EEG record is part of the protocol. Patients were divided into two groups: "classica...