ANG II promotes inflammation through nuclear factor kappa beta (NF-kB) mediated induction of cytokines and radical oxidants species (ROS). The aim of the present study was to examine the effect of TTA, a modified fatty acid, on NF-kB, pro-inflammatory markers, ROS and nitric oxide (NO) production in 2K1C hypertension. 2K1C TTA treated group had lower blood pressure (128 ± 3 mmHg) compared to 2K...

Post-translational modifications (PTMs) of histone proteins play a fundamental role in regulation of DNA-templated processes. There is also growing evidence that proteolytic cleavage of histone N-terminal tails, known as histone clipping, influences nucleosome dynamics and functional properties. Using top-down and middle-down protein analysis by mass spectrometry, we report histone H2B and H3 N...

Whether plants respond to cues produced by neighbors has been a topic of much debate. Recent evidence suggests that wild tobacco plants transplanted near experimentally clipped sagebrush neighbors suffer less leaf herbivory than tobacco controls with unclipped neighbors. Here we expand these results by showing evidence for induced resistance in naturally rooted tobacco when sagebrush neighbors ...

To test whether hypertension can cause hyperinsulinemia or insulin resistance, we performed intravenous glucose tolerance tests at 1 month and euglycemic clamps at 3 months after induction of two-kidney, one clip renovascular hypertension in rats. At 1 month, systolic pressure was higher in 21 clipped than in 12 control animals (161 +/- 5 mm Hg, range 134-187 mm Hg versus 119 +/- 3 mm Hg, range...

Individual variation in life-history trade-offs can be caused by differences in quality and age. We tested for individual variation in parental investment in incubating tree swallows (Tacyhcineta bicolor) subjected to a feather-clipping manipulation. Individual quality influenced how females were affected by feather clipping; lower quality clipped females showed a greater reduction in incubatio...

We isolated and perfused both the "clipped" and "contralateral" kidneys from Goldblatt renal hypertensive and sham-operated control rats, 1--104 days postoperatively. Responses to renal nerve stimulation were depressed in clipped kidneys from hypertensive rats (1 day postoperative), and these kidneys were supersensitive to exogenous norepinephrine (1--31 day) when compared with the contralatera...