We conducted a clinical trial to assess adoptive transfer of T cells genetically modified to express an anti-CD19 chimeric Ag receptor (CAR). Our clinical protocol consisted of chemotherapy followed by an infusion of anti-CD19-CAR-transduced T cells and a course of IL-2. Six of the 8 patients treated on our protocol obtained remissions of their advanced, progressive B-cell malignancies. Four of...

BACKGROUND The Active For Life Year 5 (AFLY5) randomised controlled trial protocol was published in this journal in 2011. It provided a summary analysis plan. This publication is an update of that protocol and provides a detailed analysis plan. UPDATE This update provides a detailed analysis plan of the effectiveness and cost-effectiveness of the AFLY5 intervention. The plan includes details ...

Yet, although it is very difficult to detect just by physical examination, it is most important that the clinician pick up developing thyroid disease in children and adults with Down’s syndrome. Hypothyroidism can affect a child with Down’s syndrome at any age as was shown in a study where none of the cases had yet presented with clinical signs; the hypothyroidism already present in the childre...

This study was conducted to evaluate the ability of dental students to administer emergency oxygen to a patient during a simulated emergency. Forty third-year (D3) and fourth-year (D4) dental students were recruited and asked to demonstrate their ability in managing a simulated angina attack. Students were tested on their knowledge related to emergency medical protocols, the time taken to obtai...

Wireless Body Area Networks (WBAN) is the recent trend for localized and personalized medical services. For that purpose, several tele-medicine architectures and WBAN frameworks for patient monitoring have been proposed. This paper presents a new medical protocol MESETP (Medical Services Transport Protocol), that underlies data delivery for both real-time and non real-time medical services. Fur...

Image-guided radiotherapy (IGRT), adaptive radiotherapy (ART), and online reoptimization rely on accurate mapping of the radiation beam isocenter(s) from planning to treatment space. This mapping involves rigid and/or nonrigid registration of planning (pCT) and intratreatment (tCT) CT images. The purpose of this study was to retrospectively compare a fully automatic approach, including a non-ri...

Much of postmodern philosophy questions the assumptions of Modernity, that period in the history of the Western world since the Enlightment. These assumptions are that truth is discoverable through human reason; that certain knowledge is possible; and furthermore, that such knowledge will provide a basis for the ineluctable progress of Mankind. The Enlightenment project is underwritten by the c...

Ubiquitous computation refers to the creation of environments with high processing and communication capacities in which the computers practically go unnoticed by the users. A context in which this vision of the future opens different lines of research is the field of health. The goal of this paper is to present a proposal for ubiquitous computation in a hospital context for the application of ...

OBJECTIVES During the last decade, evidence-based medicine has given rise to an increasing number of medical practice guidelines and protocols. However, the work done on developing and distributing protocols outweighs the efforts on guaranteeing their quality. Indeed, anomalies like ambiguity and incompleteness are frequent in medical protocols. Recent efforts have tried to address the problem ...

AIM The aim of this study was to coordinate the structured psychosocial, neurocognitive and educational follow-up of children treated for brain tumours with the medical protocol and apply the model in two Swedish healthcare regions. METHODS We invited all children living in the two regions, who had been diagnosed with a brain tumour from October 1, 2010, through June 30, 2012, to participate ...