BACKGROUND Evidence indicates that venlafaxine hydrochloride extended release (ER) effectively ameliorates anxiety symptoms. OBJECTIVES To evaluate the efficacy, safety, and tolerability of flexible-dose venlafaxine ER compared with placebo in the short-term treatment of generalized social anxiety disorder and, secondarily, to compare paroxetine with venlafaxine ER and paroxetine with placebo...

OBJECTIVE To examine the relative efficacy of intensive versus weekly cognitive-behavioral therapy (CBT) for children and adolescents with obsessive-compulsive disorder (OCD). METHOD Forty children and adolescents with OCD (range 7-17 years) were randomized to receive 14 sessions of weekly or intensive (daily psychotherapy sessions) family-based CBT. Assessments were conducted at three time p...

A video clinical global impression scale (CGI) in obsessive compulsive disorder Abderrahmane Bourredjem , Antoine Pelissolo , Jean-Yves Rotge , Nematollah Jaafari , Sebastien Machefaux , Solene Quentin , Eric Bui , Nicolas Bruno , Jean-Baptiste Pochon , Mircea Polosan , Nicolas Baup , François Papetti , Isabelle Chéreau , Christophe Arbus , Luc Mallet , Sophie Tezenas du Montcel a,m,⁎ and for t...

OBJECTIVE This study examined the confounding effect of treatment emergent physical or psychic symptoms on clinical global impression (CGI) ratings in CNS trials and examined the benefit of targeted scoring criteria on clarifying ratings and reducing scoring variance. METHODS Twenty-four raters participating in an investigator meeting training session scored a series of scripted CGI scenarios...

Patients: 262 people aged 16–40 years, with schizophrenia, schizophreniform or schizoaffective disorder (DSM-IV), presenting with first episode psychosis. Participants scored >4 on the Positive and Negative Syndrome Scale (PANSS) and had a Clinical Global Impression (CGI) severity score >4. Exclusions: substance use in previous month, received antipsychotic drugs for more than 16 weeks, unstabl...

Results Therewere significant differencesbetweenthe premorbid groups on change onthe Positive and Negative Syndrome Scale,Clinical Global Impression severity and cognitive functioningand Extrapyramidal Symptoms Rating Scale.Patients inthe ‘stable^good’premorbid group (n1⁄4251) improvedmore thanthose in the‘stable^ poor’ (n1⁄4198) and‘declining’ (n1⁄481) groups.The‘stable^good’group received the...

BACKGROUND Patients under antipsychotic treatment for schizophrenia commonly exhibit poor adherence to treatment, high rates of treatment discontinuation, and frequent treatment changes. The ETOS study aimed to identify the reasons leading physicians to decide to switch antipsychotic treatment in outpatients with schizophrenia and to evaluate the outcome of this switch. METHODS ETOS was an ob...

OBJECTIVES The aim of this randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of Ginkgo biloba extract in patients diagnosed with vascular cognitive impairment (VCI). METHODS A total of 90 patients (aged 67.1±8.0 years; 59 women) were randomly allocated (1:1:1) to receive G. biloba 120 mg, G. biloba 60 mg, or placebo during a 6-month period. Assessment...

This study assessed the efficacy, tolerability and safety of vortioxetine versus placebo in adults with recurrent major depressive disorder. This double-blind, randomized, placebo-controlled study included 608 patients [Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥ 26 and Clinical Global Impression - Severity score ≥ 4]. Patients were randomly assigned (1 : 1 : 1 : 1) to vorti...

INTRODUCTION The aim of this study was to evaluate the efficacy and safety of quetiapine fumarate extended release (XR) in the treatment of Korean subjects with acute schizophrenia. METHODS This was an 8-week, multi-center, open-label, non-comparative study to evaluate the efficacy and safety of quetiapine fumarate XR at a daily dose of 400-800 mg. Changes in total scores on the Positive and ...