OBJECTIVE To review recent data on the aetiology of cleft lip and palate. DATA SOURCES MEDLINE literature search (1986-2003). STUDY SELECTION Literature and data on aetiology of cleft lip and palate using the following key words: 'cleft lip', 'cleft palate', 'aetiology', and 'genetics'. DATA EXTRACTION Relevant information and data were reviewed by the authors. DATA SYNTHESIS Cleft lip ...

In the course of maintaining a large colony of Brittany spaniels for studying a dominantly inherited motor neuron trait, cases of sporadic complete cleft palate were observed. Without intervention, the pups with cleft palate that attempt to nurse, aspirate and die. In this study, we report on the incidence of cleft palate in this dog kindred, describe the gross morphologic characteristics of th...

Cleft lip defects are usually regarded as a single entity, with the assumption that an accompanying cleft palate represents the more severe form. The authors linked data from the Medical Birth Registry of Norway with medical records from two centralized centers to provide a population-based data set. They assessed the distribution of cleft lip only and cleft lip with cleft palate by covariate. ...

AIMS To identify prevalence of delayed detection of cleft palate, and associated factors that could lead to improved identification at neonatal clinical examination. METHODS Audit of hospital notes, parental questionnaire incorporating open ended questions, and telephone questionnaire of junior doctors in the referring hospitals incorporating fixed choice questions. RESULTS Of 344 cleft pal...

Cleft palate, the most frequent congenital craniofacial birth defect, is a multifactorial condition induced by the interaction of genetic and environmental factors. In addition to complete cleft palate, a large number of human cases involve soft palate cleft and submucosal cleft palate. However, the etiology of these forms of cleft palate has not been well understood. T-box transcriptional fact...

Congenital tumors of the oral cavity are not common.Teratoids are the most common tumors, and in rare cases are associated with cleft soft palate. In this paper a rare case of Epignathus with cleft soft palate, bifida tongue, jaw malocclusion, tongue lipoma, Hypertelorism and low-set ears has been presented. A female infant with a large mass covered with skin and hair arising from hard palate, ...

introduction: orofacial clefts are among the most common congenital anomalies. patients presenting with orofacial clefts often require surgery or other complex procedures. a cleft lip or palate can be a single anomaly or a part of multiple congenital anomalies. the reported prevalence of cleft disease and associated anomalies varies widely across the literature, and is dependent on the diagnost...

OBJECTIVE To use a Geographic Information System (GIS) approach to study the distribution and statistics of patients with cleft lip/palate in Thailand's Northeast region who get treatment at Srinagarind Hospital, Khon Kaen University. MATERIAL AND METHOD Using a GIS approach, the researchers reviewed every case with cleft lip/palate treated at Srinagarind Hospital between 1984 and 2007 to stu...

In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections. Of six loci tested, only the chromosome segment marked by N-acetyl transferase was found to affect susceptibility to 6-aminonicotinamide-induced cleft palate. This chromosome segment is known to affect glucocorticoid-...

Cleft palate following cleft lip may include a developmental disorder during palatogenesis. CL/Fr mice fetuses, which develop cleft lip and palate spontaneously, have less capability for in vivo cell proliferation in palatal mesenchyme compared with CL/Fr normal fetuses. In order to know the changes of signaling molecules contributing to cleft palate morphogenesis following cleft lip, the mRNA ...