background and objective: magnetic resonance imaging (mri) is the most sensitive technique to detect multiple sclerosis (ms) plaques in central nervous system. in some cases, the patients who were suspected to ms, whereas mri images are normal, but whether patients don’t have ms plaques or mri images are not enough optimized enough in order to show ms plaques? the aim of the current study is ev...

Although it is clear that astrocytes and microglia cluster around dense-core amyloid plaques in Alzheimer disease (AD), whether they are primarily attracted to amyloid deposits or are just reacting to plaque-associated neuritic damage remains elusive. We postulate that astrocytes and microglia may differentially respond to fibrillar amyloid β. Therefore, we quantified the size distribution of d...

We report radioiodinated chalcone derivatives as new SPECT imaging probes for amyloid β (Aβ) plaques. The monoethyleneoxy derivative 2 and allyloxy derivative 8 showed a high affinity for Aβ(1-42) aggregates with Ki values of 24 and 4.5 nM, respectively. Fluorescent imaging demonstrated that 2 and 8 clearly stained thioflavin-S positive Aβ plaques in the brain sections of Tg2576 transgenic mice...

BACKGROUND Identification of coronary plaque composition is important for selecting the treatment strategy, and 64-slice computed tomography (CT) is a noninvasive method of characterizing atherosclerotic plaques. However, the correlation between plaque characteristics detected by CT and intravascular ultrasound (IVUS) is not clear. A 40 MHz IVUS imaging system (iMap-IVUS) has recently been deve...

In Alzheimer's disease (AD), hallmark β-amyloid deposits are characterized by the presence of activated microglia around them. Despite an extensive characterization of the relation of amyloid plaques with microglia, little is known about the initiation of this interaction. In this study, the detailed investigation of very small plaques in brain slices in AD transgenic mice of the line APP-PS1(d...

purpose: to report a case of candida glabrata endophthalmitis after deep anterior lamellar keratoplasty methods: interventional case report results: a young male patient presented with asymptomatic white to cream-colored interface deposits two months after deep anterior lamellar keratoplasty. after a while, severe anterior chamber reaction together with decreased visual acuity developed. becaus...

We report a case of a very long left main coronary artery (58 mm) with septal perforators before bifurcation. The coronary arteries were seen clear of plaques. To the best of our knowledge, this case is very rare because of the existence of the first and second septal perforator arteries originating from a very long left main coronary artery.

purpose: to design and manufacture iodine 125 radioactive plaques which can be used in patients with ocular melanoma, and to evaluate the efficacy of plaques in an animal model. methods: this prospective basic study was performed in collaboration with farabi hospital and tehran atomic energy agency. the iodide 125 plaques were designed and manufactured based on the collaborative ocular melanoma...