A 16S ribosomal DNA-based PCR appeared to be a sensitive test for the detection of infection by Helicobacter pylori in 31 patients when compared with culturing and histological and serological techniques. For five patients, PCR was the only test with a positive result. H. pylori DNA was also found in gastrointestinal equipment even after standard intensive combined manual and machine cleaning. ...

To ensure that residues of Tirofiban will not carry over and cross contaminate the subsequent product, carefully designed cleaning validation techniques should be investigated. The objective of the present study was to validate simple analytical method for verification of residual Tirofiban in equipments used in the production area and to confirm efficiency of cleaning procedure. An assay metho...

The objective of this work was the development and validation of atomic absorption spectrometric (AAS) methods for the determination of residual active pharmaceutical ingredients (API) in rinse samples for cleaning validation. AAS as an indirect method for the determination of API in rinse samples can be applied when it is in the form of salt with metal ions or when the metal ion is a part of t...

In Pharmaceutical industries, it is very impo remove drug residues from the equipment and areas used. The cleaning procedure must be validated, so special attention must be devoted to the methods used for analysis of trace amounts of drugs. A rapid, sensitive and specific reverse phase ultra chromatographic (UPLC) method was developed for the quantitative determination of Albendazole in cleanin...

In this paper, we have described the active cleaning approach that was used to complement the active learning approach in the TRECVID collaborative annotation. It consists in using a classification system in order to select the most informative samples for multiple annotations, in order to improve the quality and the reliability of the annotations. We have evaluated the actual impact of the act...

BACKGROUND Clinical validation of laboratory toothbrushing tests has important advantages. It was, therefore, the aim to demonstrate correlation of tooth cleaning efficiency of a new robot brushing simulation technique with clinical plaque removal. METHODS Clinical programme: 27 subjects received dental cleaning prior to 3-day-plaque-regrowth-interval. Plaque was stained, photographically doc...

Data validation and cleaning are integral processes of the data qualitymanagement cycle. Domain specific knowledge is needed to detect and correct semantic errors. Ontologies can be used to represent valid and invalid attribute value combinations to detect and correct invalid data. We introduce reorganization operations formaintaining such an ontology in the data quality management cycle.

Cleaning validation is a process used by pharmaceutical manufacturers to ensure that their equipment and facilities are thoroughly cleaned free of any residual contaminants could potentially compromise the quality products. This guided regulatory guidelines set forth FDA European Medicines Agency (EMA) two examples such agencies.
 protocols typically required these guidelines, which outlin...