Pseudomonas aeruginosa is an opportunistic human pathogen that causes nosocomial infections. This bacterium is characterized by inherent resistance to a wide variety of antimicrobials; the inherent resistance is always mediated by antibiotic resistance genes (3, 10). A genetic element, the integron, is potentially a major agent in the dissemination of multidrug resistance among gram-negative ba...

The first integron-borne metallo-beta-lactamase gene was isolated in Hungary. The bla(VIM-4) gene is located on a class 1 integron that also carries a novel bla(OXA)-like gene. The integron is harbored by a serotype O12 Pseudomonas aeruginosa strain and shows high structural similarity to integrons isolated in Greece and Poland.

BACKGROUND/AIM Pseudomonas aeruginosa is the cause of 10% of hospital-acquired infections. The organisms are often multidrug- resistant, mediated mostly by antibiotic-resistant integrons. The aim of this research was to study integron carriage and its association with multidrug resistance in burn and nonburn clinical isolates of P. aeruginosa. MATERIALS AND METHODS A total of 112 P. aeruginos...

The presence of integrons was assessed in gut bacteria isolated from wild-caught prawns. A pseudomonad was recovered that contained a Tn402-like class 1 integron with a complete transposition module and two gene cassettes. One cassette was identical to a previously described cassette from a chromosomal class 3 integron in Delftia tsuruhatensis.

b ackg r oun d : pseudomonas aeruginosa is one of the most important oppor- tunistic pathogens responsible for various types of infections. children suffer significant morbidity and mortality due to nosocomial infections. the aim of this study was to investigate the presence of class1 integron, blabel, blaper, blakpc, blavim, blaimp and blaoxagroup-1  genes among p. aeruginosa isolates at child...

background and aims: the indiscriminate use of antibiotics can lead to antibiotic resistance in the treatment of infections caused by bacteria such as pseudomonas aeruginosa. the presence of integrons in pseudomonas is clearly associated with multidrug resistances. therefore, this study aimed at tracking class i, ii and iii integrons of antibiotic-resistant isolates of pseudomonas aeruginosa th...

Integrons are associated with a variety of gene cassettes, which confer resistance to multiple classes of antibacterial drugs. In this study we tested the frequency of class 1 and 2 integrons among multidrug-resistant Acinetobacter baumannii (MDRAB) clinical isolates. One hundred clinical isolates of A. baumannii were screened for carriage of class 1 and 2 integrons by PCR method. Results showe...

For the present report, a novel complex class 1 integron, In60, was characterized. Part of this integron includes the bla(CTX-M-9) gene and its downstream nucleotide sequence, which shares 81% and 78% nucleotide identity with those of kluA-1 beta-lactamase and orf3 of K. ascorbata, respectively. Furthermore, a new insertion sequence, IS3000, has been found in In60. PCR analysis indicates that i...

background: infections caused by pseudomonas aeruginosa or acinetobacter baumannii are of greatest concern for hospitalized patients, particularly those in intensive care units (icus). the aims of this study were to investigate the prevalence of integrons and biofilm formation among p. aeruginosa and a. baumannii isolates collected from icu and non-icu inpatients. materials and methods: a total...