Renal Oncocytomas and renal cell carcinomas (RCCs) share a common phenotype. This makes it very difficult to differentiate between the two tumors. Here, this study was to confirmed and expanded the findings that CK7 as a promising tool differentiate RCC from Oncocytomas across various geographic regions. A systematic search of databases was carried out and other relevant articles were also iden...

Background: Hepatocytes transplantation (HCTx) is an alternative method to orthotopic liver transplantation used in treatment of several liver injuries. It can be used either fresh or as encapsulated hepatocytes. Expression of Hep Par 1, CK7 and Albumin were performed to identify and analyze the transplanted isolated adult hepatocytes in hamsters spleens. Aim: This work aimed to study the expre...

BACKGROUND Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell carcinoma (SqCC) is crucial for the targeted therapy. However, the distinction between ADC and SqCC may be difficult in small FNA specimens. Here, we have retrospectively evaluated...

Introduction: Cancer is malignant disease, one of the leading cause deadth at global level. The determination origin tumors really essential for not only prognosis but also effective treatment orientation cancerous patients. Objective: Defining histopathological types epithelial and determining by CK7, CK20 other immunohistochemical markers. Patients methods: A cross-sectional study 50 patients...

Differentiating between benign hepatocellular adenoma (HA) and carcinoma (HCC) is important for making clinical management decisions but can be challenging. We have reported liver tumor patients being discrepantly diagnosed as or based on different interpretations of identical histologic pattern - acinar/pseudoglandular pattern. In the study early hepatocarcinogenesis, it was proposed more than...

For primary bladder tumors, distinguishing urothelial carcinoma (UC) invading the fibromuscular stroma of the prostate (pT4a) from in situ UC involving prostatic ducts can be difficult. Immunohistochemical markers (cytokeratin [CK]5/6, CK5, CK7, CK20, p53, p63, high-molecular-weight keratin [HMWK], androgen receptor, prostate-specific antigen [PSA], prostate specific acid phosphatase [PSAP], la...

Background and Objective: Early diagnosis of malignant pleural mesothelioma (MPM) is the key point of its treatment. The main problem is the precise diagnosis of mesothelioma and its differentiation from metastatic lung adenocarcinoma. Mesothelioma exhibits complex immunohistochemical characteristics. The aim of this study was to study hybrid immunohistochemistry in the differe...

Ayedin et al2 compared the immunohistochemical profile of this tumour with RCC and described that papillary cystadenomas are positive for cytokeratin AE1/AE3 and EMA, CK7 and negative for CK20 and RCC immunostain. Four of 5 cases were negative for CD10. This staining profile contrasts with that reported for clear cell RCC, which are typically negative for CK7 and are immunoreactive for RCC and ...

Cytokeratin (CK) expression was studied in 22 sinonasal inverted papillomas. Columnar (respiratory) epithelium in inverted papillomas abundantly expressed CK7, CK8, CK18, and CK19. Immunoreactivity for CK5/14 and CK17 was found in basal and parabasal/suprabasal cells. Transitional (cuboidal) and squamous epithelium in inverted papillomas comparably expressed CK7, CK8, CK18, and CK19. In additio...

Primary liver cancer may derive from hepatocytes or bile duct cells. Recently it has been suggested the progenitor cell compartment is also a target cell population for carcinogenesis (1). Hepatic progenitor cells (HPC) are located in the most peripheral branches of the biliary tree, i.e., the ductules and canals of Hering. Biliary epithelium is normally CK7 and CK19 positive. HPC are also immu...