PURPOSE OF REVIEW Previous studies have shown that a variety of specific renal functions exhibit circadian oscillations. This review aims to provide an update on the molecular mechanisms underlying circadian rhythms in the kidney, and to discuss how dysregulation of circadian rhythms can interfere with kidney function. RECENT FINDINGS The molecular mechanism responsible for generating and mai...

Elucidation of the cellular and molecular mechanisms of the circadian clock, along with the realization that these mechanisms are operative in both central and peripheral tissues, has revolutionized circadian biology. Further, these observations have resulted in an explosion of interest in the health implications of circadian organization and disorganization at both molecular and physiological ...

Circadian rhythms govern a large array of metabolic and physiological functions. The central clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for circadian function. We show that the HDAC activity of the NAD(+)-dependent SIRT1 enzyme is regulated in a circadian manner, correlating with rhythmic acety...

Background: spacecrafts rotate around the Earth every 90 minutes, so the 24-hour cycle turns to 90 minutes. Retinoic acid, an active metabolite of vitamin A, plays a role in regulating the circadian rhythm and its deficiency can impair the biological clock function and consequently impair the circadian rhythm of locomotor activity. The goal of the study was to assay the effects of simulated spa...

Cartilage tissues possess intrinsic circadian oscillators, which influence chondrocyte function and chondrocyte specific gene expression. However, it is not fully understood how chondrogenesis influences the circadian clock, and vice versa. Thus, we established ATDC5 cells which were stably transfected with the Bmal1:luc reporter and revealed robust circadian rhythms in ATDC5 cells during diffe...

Circadian rhythm is a biological process that regulates neuronal, metabolic, and hormonal functions following 24-hour cycle. Parkinson’s disease (PD) progressive neurodegenerative disorder, it exhibits diurnal fluctuations in motor non-motor symptoms. Recently, increasing attention has been paid to circadian dysfunction PD patients. This review summarizes the existing research on rhythms especi...

Cognitive and affective processes vary over the course of the 24 h day. Time of day dependent changes in human cognition are modulated by an internal circadian timekeeping system with a near-24 h period. The human circadian timekeeping system interacts with sleep-wakefulness regulatory processes to modulate brain arousal, neurocognitive and affective function. Brain arousal is regulated by asce...

In contrast to the highly centralised circadian clock in mammals, where the master clock resides in the anterior hypothalamic nucleus, as suprachiasmatic nucleus (SCN), the avian circadian timing machinery is more complicated with 3 circadian clock centresthe retina, hypothalamus and pineal. These three autonomous circadian oscillators interact with one another to regulate overt circadian rhyth...

Despite significant progress in elucidating the molecular basis for circadian oscillations, the neural mechanisms by which the circadian clock organizes daily rhythms of behavioral state in mammals remain poorly understood. The objective of this review is to critically evaluate a conceptual model that views sleep expression as the outcome of opponent processes-a circadian clock-dependent alerti...

n-phthaloyl gaba was administrated daily (50 mg/kg body weight-i.p) to wistar rats for 21 days and circadian rhythms of thiobarbituric acid reactive substances (tbars) and antioxidants such as reduced glutathione (gsh), catalase (cat) and superoxide dismutase (sod) were studied under constant light (ll) conditions. delayed acrophase of tbars and advanced acrophase of antioxidants (gsh, cat and ...