A novel simple, sensitive, rapid and accurate isocratic RP-HPLC method was developed validated for simultaneous determination of Dimenhydrinate Cinnarizine applying statistical experimental design. Design experiments (DoE) applied multivariate optimization the conditions method. Three independent factors like; mobile phase composition, phosphate buffer strength flow rate were employed to design...

This article explains the developed and validated rapid, timesaving, cost-effective UHPLC method for simultaneous quantification of cinnarizine, its five specified impurities (Impurity-A to E), two degradation products (cinnamyl piperazine benzhydrol), antioxidants (methylparaben propylparaben). Furthermore, when coupled with a mass spectrometer, proposed provides additional advantages confirma...

From 2001 to 2006, we performed a retrospective study of patients suffering from chronic unilateral or bilateral tinnitus that was previously ineffectively treated by oral drugs [betahistine (Betaserc), extract of Ginkgo biloba (EGb 761), tanakan (Tebokan), and cinnarizine-dimenhydrinate (Arlevert), singly or in combination]. We divided 150 tinnitus patients (80 men, 70 women) into seven treatm...

To determine the safety and efficacy, we have developed validated RP-HPLC method for simultaneous quantification of cinnarizine, its five specified impurities two degradation products in cinnarizine API, tablets capsules including antioxidants an oral suspension formulation. The chromatographic separation was achieved gradient elution mode with 1.00mL/min flow on Ascentis Express C18 (150mm, 4....

Ménière's disease and related disease of the vestibular system are common and debilitating. Current therapy is multi-modal and includes drug therapy and lifestyle adaptations. Unfortunately many of the drugs used in treatment (particularly those used to control nausea) are sedative and hamper the process of vestibular compensation. Although betahistine (Serc®), BetaSerc®); Solvay Pharmaceutical...