In order to identify the structural basis of the blood aqueous barrier in the chicken eye, the morphology of the blood vessels and epithelium of the ciliary body were examined with light microscopy, conventional electron microscopy, and the freeze-fracturing technique; the permeability properties of the vessels and epithelium were tested with intravascular injection of horseradish peroxidase (H...

Purpose To report a case of age-related hypertrophy of the nonpigmented ciliary epithelium (ARH-NPCE) clinically resembling a ciliary body melanoma and report the optical coherence tomography angiography (OCTA) findings associated with this lesion. Observations A 51-year-old male was referred for evaluation of a deeply pigmented ciliary body mass with extension through the iris root. Iridocyc...

PURPOSE To describe iris atrophy, serous detachment of the ciliary body, and ocular hypotony in a patient with chronic phase of Vogt-Koyanagi-Harada (VKH) disease. METHODS Ocular examination and follow-up including digital infrared transillumination imaging of the iris was done in a 52-year-old woman with chronic phase of VKH disease. RESULTS Infrared transillumination imaging showed extens...

PURPOSE Intraocular pressure (IOP) is known to have a strong circadian rhythm, yet how light/dark cycles entrain this rhythm is unknown. The purpose of this study was to assess whether, like the retina, the mammalian ciliary body and IOP clocks have an intrinsic ability to entrain to light/dark cycles. METHODS Iris-ciliary body complexes were obtained from period2:luciferase (PER2::LUC) mice ...

BACKGROUND Diagnostic and surgical management of severe chronic angle- closure glaucoma secondary to ciliary body cysts can be difficult to manage in a patient with oculodentodigital dysplasia. CASE PRESENTATION A 6-year old girl with oculodentodigital dysplasia, with progressive chronic angle- closure glaucoma secondary to ciliary body cysts presented to our clinic. The initial examination r...

Brinzolamide is a topical carbonic anhydrase inhibitor which reduces the production of aqueous humor in ciliary body, thereby reducing intra-ocular pressure. It formulated as an ophthalmic suspension. The pharmacokinetics ocular suspensions not well understood. objective this study was to characterize brinzolamide rabbit humor, iris-ciliary plasma, and whole blood. New Zealand White rabbits wer...