The extent to which microorganisms impair wound healing is an ongoing controversy in the management of chronic wounds. Because the high diversity and extreme variability of the microbiota between individual chronic wounds lead to inconsistent findings in small cohort studies, evaluation of a large number of chronic wounds using identical sequencing and bioinformatics methods is necessary for cl...

The care and management of patients with chronic wounds and their far-reaching effects challenge both the patient and the practitioner. Further complicating this situation is the paucity of evidence-based treatment strategies for chronic wound care. After searching both MEDLINE and Cochrane databases, we reviewed currently available articles concerning chronic wound care. Utilizing this informa...

BACKGROUND AND PURPOSE Electrical current has been recommended for use on chronic pressure ulcers; however, the ability of this modality to improve healing of other types of chronic ulcers is less well established. The purpose of this study was to examine the effect of high-voltage pulsed current (HVPC) on healing of chronic leg ulcers. SUBJECTS Twenty-seven people with 42 chronic leg ulcers ...

OBJECTIVES The targeted disruption of biofilms in chronic wounds is an important treatment strategy and the subject of intense research. In the present study, an in vitro model of chronic wound biofilms was developed to assess the efficacy of antimicrobial treatments for use in the wound environment. METHODS Using chronic wound isolates, assays of bacterial coaggregation established that aero...

Chronic ischemic wounds presenting at wound clinics are heterogeneous with respect to etiology, age of the wound, and other factors complicating wound healing. In addition, there are ethical challenges associated with collecting repeated biopsies from a patient to develop an understanding of the temporal dynamics of the mechanisms underlying chronic wounds. The need for a preclinical model of i...

Since the traditional methods of treatment have proven ineffective against chronic wounds involving biofilms, the present study evaluates the in vitro efficacy of a novel wound gel comprising an antibiofilm DispersinB ® enzyme and a broad-spectrum antimicrobial triclosan against chronic wound-associated bacteria. The antimicrobial and antibiofilm activity of DispersinB ® -triclosan wound gel wa...

The aim of the study was to determine the effects of wound, patient and treatment attributes on wound healing rate and to propose a system for wound healing rate prediction. Predicting the wound healing rate from initial wound, patient and treatment data collected in our database of 300 chronic wounds was not possible. After considering weekly follow-ups, we determined that the best prognostic ...

Beneficial and deleterious bacterial–host interactions in chronic wound pathophysiology Report Title Chronic wounds represent a major health and financial burden. Although incredible advancements in wound management have been made in the last decade, the incidences of chronic wounds continue to increase due to a rise in biofilm-associated infections. The presence of biofilm causes chronic...