Pyoderma vegetans (PV) is a rare inflammatory disorder characterized by vegetating pustules and plaques affecting the skin and mucosal membranes. It is believed that this entity is mostly associated with inflammatory bowel disease (IBD), chronic malnutrition, human immunodeficiency virus (HIV), malignancies, and other immunocompromised states. Pyoderma vegetans occurs more commonly in young and...

BACKGROUND Acne inversa is a chronic, suppurative relapsing inflammatory skin disease that primarily affects the axillae, perineum and inframammary regions. Evidence suggests that the innate immune system is involved in the pathogenesis of acne inversa. OBJECTIVE To investigate the role of the innate immune system in acne inversa. METHODS Skin biopsies were obtained from inflammatory skin l...

psoriasis is an common, chronic, recurrent, inflammatory disease of the skin, characterized by red scaling plaques on the skin surface. the morphology of psoriatic lesions allows classification of the different types of psoriasis that included plaque type, pustular type and erythrodermic type. i have studied the relationship between distribution of rh and abo blood groups in 110 psoriatic patie...

AIMS To measure Langerhans' cells in skin of patients treated by bone marrow transplantation who developed chronic graft versus host disease (GvHD); to determine whether the reduction in Langerhans' cells resulted directly from the GvHD or from other factors, such as the immunosuppressive regimens used in bone marrow transplant patients. PATIENTS AND METHODS Lesional and nonlesional skin spec...

background: marjolin's ulcer is a rare, aggressive condition that arises on chronic skin lesions and diseases. in this article, we will report 83 cases of this disease. methods: retrospectively, we retrieved 83 records of patients with cancer arising from chronic skin conditions. data concerning demography, type of original skin insult, time interval between original lesion and cancer, cancer h...

background: marjolin's ulcer is a rare, aggressive condition that arises on chronic skin lesions and diseases. in this article, we will report 83 cases of this disease. methods: retrospectively, we retrieved 83 records of patients with cancer arising from chronic skin conditions. data concerning demography, type of original skin insult, time interval between original lesion and cancer, can...

BACKGROUND Arsenic is a unique human carcinogen in that it causes lung cancer by exposure through ingestion (in drinking water) as well as through inhalation. Less is known about nonmalignant pulmonary disease after exposure to arsenic in drinking water. METHODS We recruited 108 subjects with arsenic-caused skin lesions and 150 subjects without lesions from a population survey of over 7000 pe...

We assessed the dermatological manifestations associated with chronic hepatitis C virus (HCV) infection and their association with liver status. Of 155 patients with chronic HCV infection in Cairo, Egypt, 71 (45.8%) had dermatological manifestations: pruritus without evident skin lesions (21.3%), pigmented purpuric eruption (5.2%), aphthous ulcer and lichen planus (3.9% each), leukocytoclastic ...

Herpes simplex virus type 1 (HSV-1) causes chronic blepharitis and conjunctivitis as well as keratitis in humans. The pathogenesis of these inflammatory ocular and dermal lesions is not well understood. We have examined the persistence of HSV-1 DNA and its relationship to inflammatory lesions in the conjunctiva and eyelid skin of mice which were inoculated with HSV-1 by the corneal route. Viral...

 Abstract Background: Psoriasis is a chronic proliferative condition of the skin. Its accurate pathogenesis has not been known yet, but interactions between genes and environmental factors have been implicated in its initiation. The role of malassezia in psoriasis is still undetermined, but several reports have associated these lipophilic yeasts with the development of skin lesions in psoriasis...