Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved i...

Wound pain is a serious problem for elderly patients suffering from chronic leg ulcers, and it may lead to reduced wound healing rates and reduced quality of life. Biatain-Ibu Non-adhesive (Coloplast A/S), a new pain-reducing moist wound healing dressing containing ibuprofen was tested for pain reduction, safety, and efficacy on 10+2 patients in a single-blinded crossover study against Biatain ...

Methods of identifying chronic wounds that will heal in a timely, coordinated fashion and those that will not, together with novel therapeutic strategies, are vital for progression in the field of wound healing. Interleukin (IL)-7 has been associated with various biological and pathological processes. The present study explored the potential role of IL-7 in wound healing. IL-7 expression levels...

Chronic non-healing cutaneous wounds are often vulnerable in one or more repair phases that prevent normal healing and pose challenges to the use of conventional wound care modalities. In immunosuppressed subject, the sequential stages of healing get hampered, which may be the consequences of dysregulated or stagnant wound inflammation. Photobiomodulation (PBM) or low-level laser (light) therap...

Georgina Gethin is HRB-Research Fellow, Department of Nursing and Midwifery, RCSI, Dublin, Ireland Wound healing is a complex, multifaceted process which is influenced by both intrinsic and extrinsic factors. The pH of the wound can affect many factors including oxygen release, angiogenesis, protease activity, and bacterial toxicity. Chronic non-healing wounds have an elevated alkaline environm...

Inflammation is a fundamental component of the normal adult wound healing response occurring even in the absence of infection. It performs many beneficial roles such as the clearing of damaged cells and extracellular matrix (ECM), the removal of pathogens that might otherwise multiply and spread, and the secretion of mediators that regulate other aspects of wound healing such as proliferation, ...

Wound bed preparation is a new approach that integrates proven concepts to build a platform for the treatment of chronic wounds. It organizes currently approved medical procedures and products into a holistic approach that can be used to evaluate and remove barriers to the wound-healing process. Removal of such barriers allows for optimal wound repair and healing. To address these barriers, a s...

• Non viable wound tissue (slough and/or necrosis). • Lack of healthy granulation tissue (wound tissue may be pale, greyish and avascular). • No reduction in wound size over time. • Recurrent wound breakdown. Numerous molecular and biochemical imbalances are found within the chronic wound environment, including elevated inflammatory cytokines, elevated matrix metalloproteinases (MMPs) and decre...

Objective: Burn wound healing is one of the problems of medical sciences and it is of great importance to find a drug or substance that can heal burn wounds with minimum complications. The present study aimed to evaluate the effect of ointment-based egg white on healing second-degree burn wounds. Materials and Methods: In the present triple-blind clinical...