BACKGROUND In young Chinese men of the highland immigrant population, chronic mountain sickness (CMS) is a major public health problem. The aim of this study was to measure the disease burden of CMS in this population. METHODS We used disability-adjusted life years (DALYs) to estimate the disease burden of CMS. Disability weights were derived using the person trade-off methodology. CMS diagno...

This study explored the changes in bone marrow CD235a+ nucleated red blood cell apoptosis and signal pathways patients with chronic mountain sickness. We collected data from 21 sickness 20 non-chronic patients. Bone mononuclear cells, flow cytometry is used to detect apoptotic index of cells determine mitochondrial membrane potential; reverse transcription quantitative polymerase chain reaction...

especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a year (monthly) by publishes original papers that deal with diverse area of research in applied physiology,

The purpose of the study was to investigate determinants of acute mountain sickness after rapid ascent to high altitude. A total of 21 climbers were studied ascending from <1,200 m to Capanna Regina Margherita, a hut in the Alps at 4,559 m, within <24 h. During their overnight stay at 4,559 m, breathing patterns and ventilation were recorded by calibrated respiratory inductive plethysmography a...

BACKGROUND Rhodiola crenulata (R. crenulata) is widely used to prevent acute mountain sickness in the Himalayan areas and in Tibet, but no scientific studies have previously examined its effectiveness. We conducted a randomized, double-blind, placebo-controlled crossover study to investigate its efficacy in acute mountain sickness prevention. METHODS Healthy adult volunteers were randomized t...

OBJECTIVES To assess the efficacy of three different daily doses of acetazolamide in the prevention of acute mountain sickness and to determine the lowest effective dose. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline and Embase along with a hand search of selected bibliographies. No language restrictions were applied. STUDY SELECTION Randomised controlled trials assessi...