methods and materials: hepatitis b virus dna was detected by conventional pcr in some of the serum samples obtained from hbsag-positive chronic hepatitis b (chb) patients who were referred to health centers of shahrekord for routine monitoring of the disease. subsequently, using real-time pcr, the dna samples were used for genotyping and analysis of resistance to lamivudine. results: the dna wa...

conclusions we introduced an anti-hbsp antibodies elisa, designed for locally circulating hbv strains. correlation observed of anti-hbsp with liver fibrosis staging regardless of viral replication and liver inflammation suggests anti-hbsp antibodies as possible indicator for hbv-associated liver fibrosis. results seven out of eighty (9%) chb patients were positive for anti-hbsp antibodies. mean...

objectives in this study, the association of tgf-β1 +915g/c and -509c/t gene polymorphisms with chronic hepatitis b was evaluated in iranian patients. materials and methods a population-based case–control study was conducted in taleghani hospital, tehran. a number of 220 patients with chronic hepatitis b and the same number of healthy control subjects were designated the case and the control gr...

This study assessed the seroepidemiology of Toxoplasma gondii, Hepatitis B Virus and their co-infection infection in women of child-bearing age in communities in Osun State, Nigeria. The study also determines the factors that facilitate the organisms among the studied groups and possible interaction between the prevalence of infection and the risk factors. These were done with a view to providi...

Liver disease, particularly viral hepatitis, is increasingly common. The most frequent causes of long-term, or chronic, viral hepatitis are persistent infections with the hepatitis B or hepatitis C virus. Worldwide, 400 million people are chronic carriers of the hepatitis B virus [1]. Each year, between 500,000 to 1.2 million people die from progression of this viral infection, making it the 10...

background: more than 350 million people are chronic carriers of hepatitis b virus (hbv) and because of the high hbv-related morbidity and mortality, the global disease burden of hbv is substantial. in patients with hbeag–negative chronic hepatitis b (chb) with serum alanine aminotransferase (alt) levels, 1-2 × upper limit of normal (uln) and hbv dna load of 10000 to 100000 copies/ml, liver bio...

800x600 hepatitis b virus (hbv) infection is the main cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (hcc). several factors such as serum hbv dna level, genotype and specific viral mutations have been clarified to determine disease progression of chronic hepatitis b. among these, mutations can also occur in chronic hbv patients with antiviral treatment such as lamivudine the...

conclusions this study showed a low rate of isolated anti-hbc and occult hbv infection in hd patients. it can be due to improvement of people’s knowledge about hbv transmission routes, hbv vaccination of hd patients and regular surveillance of hbv infection. results a hundredpatients with a mean age of 58.5 ± 16.1 years were enrolled in this study. in total, 56.7% were male and 43.3% female. an...

background hepatitis b is the most common chronic viral infection in humans and the most common cause of death among viral hepatitis. as 70% to 80% of chronic hepatitis cases are caused by hbv in iran, this virus alone is considered the most important cause of liver diseases and the major cause of mortality arising from viral hepatitis cases in iran. objectives we planned this study to determin...