• We propose 7 ways for nucleosome binding proteins to affect higher order structure. Choices on nucleosomal array conditions impact protein and overall Chromatin phase separation is driven by a range of interactions the nucleosome. The regulation chromatin biology ultimately depends manipulation its smallest subunit, that bind operate do so, while their substrate part polymer embedded in dense...

Polymer physics, comparing ways to assess chromatin structure and taking in tales at the Italian seaside.

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

although the genome is defined by its primary sequence, its functional properties, are determined by far more complex mechanisms and depend on multiple layers of nuclear organization. the architecture of the nucleus includes two overlapping structures: the chromatin and a framework structure named the nuclear matrix. ultra-structural studies reveal that the nuclear matrix is a network consistin...