Article history: Received 2 October 2008 Accepted 22 October 2008 0957-4166/$ see front matter 2008 Elsevier Ltd. A doi:10.1016/j.tetasy.2008.10.024 * Corresponding author. E-mail address: [email protected] (S. N Novel multifunctional chemotypes based on a-tetralone, a-indanone, and chromanone have been synthesized by a chemo-enzymatic approach by applying an enzymatic irreversible tr...

Chemoprevention is considered a new strategy in fighting diverse types of cancer. To influence cancer development and progression, signaling pathways, for example, enzymes like cyclooxygenase-2, transcription factors like NF-kB, and several metabolic processes leading to activation or deactivation of carcinogenic agents, are envisaged as promising approaches. Cytochrome P450 (CYP) enzymes activ...

The title compound, C(12)H(14)O(3), consists of a chromanone unit with an -OH substituent at the 4-position and methyl substituents on the remaining C atoms of the aromatic ring. The fused pyran-one ring adopts a distorted envelope conformation with the methyl-ene group adjacent to the carbonyl carbon as the flap atom. The crystal structure is stabilized by classical O-H⋯O hydrogen bonds and we...

A series of 6-hydroxy-7-methoxy-4-chromanone- (2a-e) and chroman-2-carboxamides (3a-e) were synthesized and their antioxidant activities were evaluated. While compounds 2a-e were less active, compounds 3a-e exhibited more potent inhibition of lipid peroxidation initiated by Fe(2+) and ascorbic acid in rat brain homogenates. Among them, N-arylsubstituted-chroman-2-carboxamides (3d and 3e) exhibi...

objective(s): chalcones and their rigid analogues represent an important class of small molecules having anticancer activities. therefore, in this study the synthesis and cytotoxic activity of new 3-benzylidenchroman-4-ones were described as rigid chalcone analogues.   materials and methods: the reaction of resorcinol with 3-chloropropionic acid in the presence of cf3so3h was afforded correspon...

chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4h,10h-pyrano[2,3-f]chromene-4,10-diones as glyasperin analogues were synthesized in four steps from known 4-chromone 1. the key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization re...