OBJECTIVE To determine if curcumin has an antiproliferative effect on leiomyoma cells via apoptosis induction and whether curcumin impacts extracellular matrix (ECM) production by assessing the fibronectin expression in leiomyoma cells treated with curcumin. DESIGN Tissue culture study of immortalized human leiomyoma and patient-matched myometrial cells treated with curcumin. SETTING Univer...

INTRODUCTION Benign metastasizing leiomyoma in the lung is a very rare disease characterized by the growth of uterine leiomyoma tissue. In most cases there is a previous history of hysterectomy for uterine leiomyoma. CASE PRESENTATION A 50-year-old Asian woman underwent a total abdominal hysterectomy for uterine leiomyoma at the age of 37 years old. She was referred to our hospital because of...

Cotyledonoid leiomyoma is very rarely described variant of benign uterine leiomyoma. Roth et al. [1] reported a series of four cases of leiomyoma characterized by alarming extra uterine growth with a dissecting myometrial component. Because of its striking resemblance to placenta, the term cotyledonoid dissecting leiomyoma was coined for this peculiar variant. It is also called Sternberg Tumor ...

Uterine leiomyomas develop during the reproductive years and regress after menopause, indicating ovarian steroid-dependent growth potential. Although the clinical and biochemical observations have traditionally supported an important role for estrogen in the promotion of leiomyoma growth, there is also increasing evidence to suggest the involvement of progesterone in the pathogenesis of leiomyo...

advances in optical coherence tomography have enabled a better appreciation of the role of pathologic choroidal changes in a variety of retinal disease. a “pachychoroid” (pachy-[prefix]: thick) is defined as an abnormal and permanent increase in choroidal thickness often showing dilated choroidal vessels and other structural alterations of the normal choroidal architecture. central serous c...

that affects women with a history of a uterine leiomyoma. However, a benign metastasizing leiomyoma without a history of previous surgery has rarely been reported. Typical radiographic findings include well-circumscribed solitary or multiple pulmonary nodules ranging from a few millimeters to several centimeters in diameter and scattered among the normal interstitium. We report a case of abenig...

AIM The present study was undertaken to explore the relationship between environmental exposure and risk of uterine leiomyoma in women using an epidemiologic survey. SUBJECTS AND METHODS We conducted a case-control survey of premenopausal Han women aged 30-50 years in Nanjing. The subjects included 600 patients with uterine leiomyoma confirmed at the Affiliated Zhongda Hospital of Southeast U...

INTRODUCTION Leiomyoma is a form of benign tumor originated in hypertrophy of the smooth muscles, which is most prevalent in the uterus and gastrointestinal tract. However, Leiomyoma originating from smooth muscle at the vessels lying on deep soft tissue is very rare. CASE REPORT Our case was a rare case of leiomyoma originating from the axillary region, which was initially diagnosed as a fib...

although bladder leiomyoma is rare, this is the most frequent nonepithelial benign tumor of the bladder. symptoms and treatment depend on location and size of the lesion as well. the optional treatment is a total enucleation or partial cystectomy, although in biopsy proved cases watchful waiting is an option, surgery should be considered as the tumor grows or symptoms are observed. the etiology...

Uterine leiomyoma is the most common tumour in women with a reported incidence of 25-30%. The tumors are benign, composed of smooth muscle cells with variable amount of collagen - rich fibrous tissue. It is well established that accumulation of extracellular matrix in leiomyoma is key feature of tissue fibrosis. However, the pathogenesis of leiomyoma is still unclear. The aim of this study was ...