The gonadotropin receptors associated with plasma membrane fractions were solubilized by detergents, including Triton X-100, Lubrol WX, Lubrol PX and sodium deoxycholate before and after equilibration with 125I-labelled human chorionic gonadotropin. The binding activity remained in solution even after centrifugation at 300 000 X g for 3 h. The solubilized gonadotropin receptor or gonadotropin r...

The denaturation of chorionic gonadotropin in 40 per cent aqueous urea solution has been found exceptional with respect to both the heat of activation and entropy of activation, but similar to other protein denaturations when compared on the basis of free energy of activation (1). The low rate (2) of inactivation of mare serum gonadotropin in 40 per cent aqueous urea solution at 37.5”, along wi...

Treatment of the BeWo line of choriocarcinoma cells with methotrexate in doses that inhibit DNA synthesis causes a tenfold increase in synthesis of human chorionic gonadotropin and a threefold increase in activity of placental alkaline phosphatase. No concomitant increase in lactic dehydrogenase activity occurs under these conditions. This effect of methotrexate can be blocked by simultaneous a...

The paper titled “The Effects of Fetal Gender on Serum Human Chorionic Gonadotropin and Testosterone in Normotensive and Preeclamptic Pregnancies” [1], published in Journal of Pregnancy, has been retracted as it is found to contain a substantial amount of material from the paper “Human chorionic gonadotropin and testosterone in normal and preeclamptic pregnancies in relation to fetal sex,” auth...

The current work aimed to study the effect of preeclampsia on maternal serum level of beta subunit of human chorionic gonadotropin and maternal plasma level of adenosine deaminase. Ninety pregnant women with gestational age 24 26 weeks were selected for this study, they were classified into three groups: group 1 consists of 30 women with normal pregnancy, group 2 consists of 30 patients with mi...

Urinary estradiol production rates, plasma estradiol, and peripheral conversion of dehydroepiandrosterone sulfate (DHEAS) to estradiol were explored in patients whose neo plasms made human chorionic gonadotropin and/or human chorionic gonadotropin ßfragments. In five men with choriocarcinoma, estradiol production was elevated, plasma estradiol was high, and DHEAS conversion to estradiol ranged...

malignant neoplasms (MNP). The frequency of PNS in MNP ranges from 1 to 20 % according different authors. One the manifestations is acne, which occurs against background neoplasm due hormonal disorders. presented article describes a clinical case patient with mixed germ cell tumor and metastases retroperitoneal lymph nodes. produced human beta-chorionic gonadotropin, led development acne as PNS...

Human chorionic gonadotropin (hCG) is useful in evaluating and monitoring early pregnancy as well as trophoblastic disease. Here we describe the management of women with elevated serum human chorionic gonadotropin in a case of a 51-year-old female who was unsuccessfully treated for ectopic pregnancy. She was subsequently diagnosed with pituitary hCG production, which should be considered as dif...

A determination was made of the gestational interval over which the Subhuman Primate Pregnancy Test, a hemagglutination inhibition test for urinary chorionic gonadotropin, accurately indicated conception and the continuation of pregnancy in an orangutan (Pongo pygmaseus). The initial positive diagnostic test response occurred about 8 months before parturition and positive responses continued th...