Choriocarcinoma is a gestational trophoblastic disease that carries high mortality. As this disease is highly responsive to chemotherapy, early diagnosis could lead to a favorable outcome. We report a case of metastatic pulmonary choriocarcinoma presented with hemoptysis and respiratory failure in a young woman at her third trimester. This report discusses the dilemma in deriving the diagnosis ...

Introduction: Choriocarcinoma is a rare but highly malignant trophoblastic neoplasm. Cases of its coexistence with or after a “normal” pregnancy are extremely rare. Intraplacental choriocarcinoma is rare, and usually results in maternal metastasis at the time of diagnosis. Case presentation: We present the case of a 29 year-old gravida 1 para 0 Chinese woman who delivered a viable 3,140 g femal...

background: the pathogenesis of gestational trophoblastic disease (gtd) is not clearly known. objective: in this study, immunoexpression of proteins bcl-2 and beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of gtd pathogenesis. materials and methods: bcl-2 and bec...

Trophoblastic diseases are mainly hydatidiform mole and choriocarcinoma, where the latter is usually the sequela of molar pregnancy and malignant systemic disease with general metastases destructing various tissues and organs till she die. High level urinary hCG, real-time B-mode and color Doppler imaging detect hydatidiform mole in early gestation, postmolar persistent trophoblastic disease is...

BACKGROUND Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with choriocarcinoma develop pulmonary metastases, but for patients with a respiratory condition, choriocarcinoma with lung metastasis is a relativ...

OBJECTIVE To report the clinical characteristics, pathologic findings and treatments of a patient with a Caesarean scar choriocarcinoma. PATIENT HISTORY A 22-year-old woman had a diagnosis of primary gestational choriocarcinoma in a uterine Caesarean scar misdiagnosed as a normal Caesarean scar pregnancy. The patient underwent selective uterine artery embolization coupled with methotrexate ar...

Background: Choriocarcinoma is a rare, aggressive subtype of gestational trophoblastic neoplasia. The diagnosis of metastatic choriocarcinoma in the setting of a viable intrauterine pregnancy is exceedingly rare and often associated with feto-maternal hemorrhage. Case: An otherwise healthy Gravida 1 Para 0 at 34 weeks gestational age presented with metastatic choriocarcinoma and a viable fetus....

•We report a choriocarcinoma coexisting with an epithelioid trophoblastic tumor.•Chemotherapy with methotrexate, etoposide, and actinomycin-D was efficacious.•Choriocarcinoma with epithelioid trophoblastic tumor may benefit from chemotherapy.

BACKGROUND Choriocarcinoma syndrome is known as a lethal complication from tumoral hemorrhage, which frequently occurs at the site of tumor metastasis. CASE PRESENTATION A 59-year-old man with 60-pack-year smoking history was referred to our hospital because of hemoptysis. Chest computed tomography (CT) showed a 28 × 18 mm spiculated nodule with a cavity infiltrating the left upper lobe. A tr...

Choriocarcinoma is a pure epithelial tumor composed of syncytiotrophoblastic and cytotrophoblastic cells with common metastases to the lung, vagina, liver, kidney, and brain [1]. Metastasis to the breast is very rare [2]. Since choriocarcinoma is a rapidly invasive, widely metastasizing malignancy with good response to chemotherapy, it is important to obtain early diagnosis for better outcome [...