Abszrucz: The study of the functioning of cholinesterases and in particular the identification of the clearance of enzymatic products from the active site, is undertaken by two different photoregulatory methodologies. A mechanism-based photo-inactivation of the cholinesterases is proposed to map this route of clearance. The use of radiolabeled probes will permit to identify the modified amino a...

The cholinesterases, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of AChE in terminating transmitter action in the peripheral and central nervous system is well understood. However, both knowledge of the function(s) of the cholinesterases in serum, and of their metabolic and endocrine regu...

The concept of an electrostatic motif on the surface of biological macromolecules as a definite topographical pattern of electrostatic potentials in three-dimensional space, provides a powerful tool for identification of functionally important regions on the surface of structurally related macromolecules. Using this approach, we identify a functional region common to cholinesterases (ChEs) and ...

The hydrolytic enzymes acetyl- and butyryl-cholinesterase, the cell adhesion molecules neuroligins, and the hormonogenic macromolecule thyroglobulin are a few of the many members of the α/β hydrolase fold superfamily of proteins. Despite their distinctive functions, their canonical subunits, with a molecular surface area of ~20,000 Ų, they share binding patches and determinants for forming hom...

This brief review describes the reactions of organophosphorus compounds with cholinesterases, neuropathy target esterase, and phosphoric triester hydrolases with respect to their toxicity. It also describes antidotes, protectors, and decontaminating agents against organophosphates.

Two cholinesterases have been found in vertebrates, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). These enzymes are present the gilthead seabream, AChE brain muscle BChE muscle. Cholinesterases used as biomarker of effect environmental monitoring studies. However, there few studies about influence biometric parameters on ChE. This paper possible biological factors cholinesterase...

The effect of concentration and pH on the miotic activity of five acetylcholine-like drugs were studied in the intact mouse eye. The data suggests that it is mainly the nonionized form of the drug which contributes to its miotic activity. Acetylcholine-like drugs, degradable by cholinesterases, exert their miotic activity at higher concentrations than do those which are resistant to enzymatic h...