نتایج جستجو برای: cholinesterase enzyme inhibitory

تعداد نتایج: 362322  

2009
Natarajan Suganthy Shunmugiahthevar Karutha Pandian Kasi Pandima Devi

Dementia is a chronic progressive mental disorder, which adversely affects memory, thinking, comprehension, calculation and language. Some of the most common dementias are Alzheimer’s disease, Parkinsonism, Dementia with Lewy Bodies and Myasthenia gravis. All of these disorders are related to abnormalities in the central cholinergic system, which shows a decline in acetylcholine (ACh) level due...

Journal: :The Biochemical journal 1960
L C Blaber N H Creasey

Previous investigators (Frawley, Hagan & Fitzhugh, 1952; Davison, 1955; Kewitz & Nachmansohn, 1957) have observed that the rate of recovery in vivo of inhibited brain true cholinesterase depended on which inhibitor was used. With diiwopropyl phosphorofluoridate (Frawley et al. 1952; Davison, 1955; Kewitz & Nachmansobn, 1957) recovery was slow, whereas with tetraethyl pyrophosphate (Davison, 195...

Journal: :شیلات 0
نیما شیری دانشجوی کارشناسی ارشد،گروه شیلات، دانشکدة منابع طبیعی، دانشگاه تهران، ایران علیرضا میرواقفی دانشیار، گروه شیلات، دانشکدة منابع طبیعی، دانشگاه تهران، ایران خلیل طالبی جهرمی استاد گروه گیاه پزشکی، دانشکدة علوم کشاورزی، دانشگاه تهران، ایران غلامرضا رفیعی استاد گروه شیلات، دانشکدة منابع طبیعی، دانشگاه تهران، ایران

biomarkers are assigned as early warning systems regarding aquatic organisms exposed to pollutants. among which, however, measurement of esterase enzymes activity specially cholinesterase of fish tissues, is a marker for exposure to organophosphate pesticide and carbamates, and this biomarker has been used widely in broad range of investigations. a number of capoeta capoeta gracilis (:cyprinida...

2016
Adriana F. L. Vilela Bárbara M. Frugeri André L. F. Sarria Rodrigo O. S. Kitamura João B. Fernandes Maria F. G. F. Silva Carmen L. Cardoso

A new series of Mannich bases derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes and two primary amines, and their Cu complexes were synthesized and evaluated for their potential as selective cholinesterase inhibitors (ChEIs). Immobilized capillary enzyme reactors (ICERs) bearing butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were used not only for the ...

Journal: :Istanbul university journal of pharmacy 2021

Background and Aims: Bongardia chrysogonum (L.) Spach (Berberidaceae), an ancient medicinal plant in Eastern Mediterranean countries, is traditionally used for the treatment of epilepsy, hemorrhoids, urinary system infections gastrointestinal disorders. This study was designed to evaluate potential neuroprotective anticancer effects different parts from B. chrysogonum. Material Methods: Leaf,...

2013
Jiangke Qin Wenli Lan Zhong Liu Jun Huang Huang Tang Hengshan Wang

BACKGROUND Alzheimer's disease (AD), a progressive and degenerative disorder, has become one of the severe problems among the aged population all over the world. To use cholinesterase inhibitor drugs has become the most predominant treatment strategy for AD. RESULTS A series of novel 1, 3-dihydroxyxanthone Mannich bases derivatives (1a ~ 4e) were synthesized, structure elucidated and evaluate...

Journal: :Letters in Drug Design & Discovery 2023

Background: Alzheimer's disease (AD) is the most common brain disorder and remains a major health concern worldwide. Considering highly complex mechanisms of AD, search for agents based on multitarget-directed ligands (MTDLs) strategy to treat AD may be more promising than traditional “one drug-one target” strategy. Inhibition Poly (ADP-ribose) polymerases-1 (PARP-1) has potentially therapeutic...

ژورنال: سلامت کار ایران 2012
باکند, شهناز, دهقانی, یاسر , مصدق, محمد حسین , میرمحمدی, سید جلیل , گوهری, محمودرضا,

  Background and Aims: Organophosphate compounds are the most popular insecticides with the widespread application in pest control. These toxic compounds interfere with the blood cholinesterase and inhibit the cholinestarse activity.Measurement of Cholinesterase activity is widely used for diagnosis of poisoning and adverse effects caused by pesticides. Green-house workers are one of the import...

Journal: :Annals of clinical and laboratory science 1988
D Trundle G Marcial

Human cholinesterase exists in two forms--acetylcholinesterase located in tissue microsomes and red blood cells and serum cholinesterase found in serum or plasma. The two enzymes display marked differences in structure, substrate specificity, biological function, and origin. Contemporary methods employ acylthiocholine as substrate for serum cholinesterase and a second coupled reaction of thioch...

Journal: :Journal of Chromatography A 2021

• First time HPTLC- Fusarium avenaceum bioassay using mycelium suspension HPTLC-EDA combined with HPTLC-DART-HRMS and HPTLC-ESI-HRMS Preparative-scale isolation of eight multipotent clerodane diterpenes cholinesterase, glucosidase, amylase microbial inhibitory potential compounds Giant goldenrod ( Solidago gigantea Ait.) root extract was screened for bioactive by high-performance thin-layer chr...

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