Dementia is a chronic progressive mental disorder, which adversely affects memory, thinking, comprehension, calculation and language. Some of the most common dementias are Alzheimer’s disease, Parkinsonism, Dementia with Lewy Bodies and Myasthenia gravis. All of these disorders are related to abnormalities in the central cholinergic system, which shows a decline in acetylcholine (ACh) level due...

Previous investigators (Frawley, Hagan & Fitzhugh, 1952; Davison, 1955; Kewitz & Nachmansohn, 1957) have observed that the rate of recovery in vivo of inhibited brain true cholinesterase depended on which inhibitor was used. With diiwopropyl phosphorofluoridate (Frawley et al. 1952; Davison, 1955; Kewitz & Nachmansobn, 1957) recovery was slow, whereas with tetraethyl pyrophosphate (Davison, 195...

biomarkers are assigned as early warning systems regarding aquatic organisms exposed to pollutants. among which, however, measurement of esterase enzymes activity specially cholinesterase of fish tissues, is a marker for exposure to organophosphate pesticide and carbamates, and this biomarker has been used widely in broad range of investigations. a number of capoeta capoeta gracilis (:cyprinida...

A new series of Mannich bases derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes and two primary amines, and their Cu complexes were synthesized and evaluated for their potential as selective cholinesterase inhibitors (ChEIs). Immobilized capillary enzyme reactors (ICERs) bearing butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were used not only for the ...

Background and Aims: Bongardia chrysogonum (L.) Spach (Berberidaceae), an ancient medicinal plant in Eastern Mediterranean countries, is traditionally used for the treatment of epilepsy, hemorrhoids, urinary system infections gastrointestinal disorders. This study was designed to evaluate potential neuroprotective anticancer effects different parts from B. chrysogonum. Material Methods: Leaf,...

BACKGROUND Alzheimer's disease (AD), a progressive and degenerative disorder, has become one of the severe problems among the aged population all over the world. To use cholinesterase inhibitor drugs has become the most predominant treatment strategy for AD. RESULTS A series of novel 1, 3-dihydroxyxanthone Mannich bases derivatives (1a ~ 4e) were synthesized, structure elucidated and evaluate...

Background: Alzheimer's disease (AD) is the most common brain disorder and remains a major health concern worldwide. Considering highly complex mechanisms of AD, search for agents based on multitarget-directed ligands (MTDLs) strategy to treat AD may be more promising than traditional “one drug-one target” strategy. Inhibition Poly (ADP-ribose) polymerases-1 (PARP-1) has potentially therapeutic...

Human cholinesterase exists in two forms--acetylcholinesterase located in tissue microsomes and red blood cells and serum cholinesterase found in serum or plasma. The two enzymes display marked differences in structure, substrate specificity, biological function, and origin. Contemporary methods employ acylthiocholine as substrate for serum cholinesterase and a second coupled reaction of thioch...

• First time HPTLC- Fusarium avenaceum bioassay using mycelium suspension HPTLC-EDA combined with HPTLC-DART-HRMS and HPTLC-ESI-HRMS Preparative-scale isolation of eight multipotent clerodane diterpenes cholinesterase, glucosidase, amylase microbial inhibitory potential compounds Giant goldenrod ( Solidago gigantea Ait.) root extract was screened for bioactive by high-performance thin-layer chr...