objectives: psychotropic drug use in the elderly with chronic schizophrenia is an important issue in the field of psychiatry. the main goal of this study was to clarify the pattern of such drug use in these patients, in order to consider such therapy plan and focus on its cost attributing measures, for a more reasonable quality of care program. methods: in this descriptive study, participants i...

Acute headache is a very frequent symptom, responsible for a significant percentage of caseload at primary care units and emergency rooms. Chlorpromazine is easily available in such settings. The aim of this study is to conduct a randomized, placebo-controlled, double-blind study to assess the efficacy of chlorpromazine on the acute treatment of episodic tension-type headache. We randomized 30 ...

Caspian kutum, Rutilus frisii kutum, is one of the most commercially important fish species in the Caspian Sea, but there are few reports about the endocrinology of induced spawning in this fish. In the present study, 54 individuals of female broodstocks of Kutum were studied for quantity and quality of propagation index, during March and April 2007. Hormone treatments include: LHRH-A2 (1 ?g kg...

The study examined the effect of some typical and atypical antipsychotic drugs on mouse lymphocyte metabolic and proliferative activity in vitro. The typical antipsychotic drug chlorpromazine (3 × 10 , 10 and 10 M), significantly inhibited H-thymidine incorporation into C57BL/6 mouse spleen cells stimulated by concanavalin A (Con A), lipopolysaccharide (LPS) or pokeweed mitogen (PWM). Chlorprom...

The study examined the effect of some typical and atypical antipsychotic drugs on mouse lymphocyte metabolic and proliferative activity in vitro. The typical antipsychotic drug chlorpromazine (3 x 10(-6), 10(-5) and 10(-4) M), significantly inhibited 3H-thymidine incorporation into C57BL/6 mouse spleen cells stimulated by concanavalin A (Con A), lipopolysaccharide (LPS) or pokeweed mitogen (PWM...

The experiment was conducted to investigate the effects of dietary vitamin K on survival, growth and tissue vitamin K concentrations of abalone, Haliotis discus hannai. Eight purified diets were formulated to provide a series of graded levels of menadione sodium bisulfite (MSB) (0-320 mgkg(-1) diet). The brown alga, Laminaria japonica, was used as a control diet. Abalone juveniles of similar si...

The use of cisplatin may be associated with severe nausea and vomiting. Two separate, randomized, double-blind trials, comparing the anti-emetic effect of chlorpromazine with placebo and chlorpromazine with droperidol, were conducted in patients receiving cisplatin for ovarian cancer. Chlorpromazine was statistically superior to placebo in the control of nausea and vomiting in those patients tr...

BACKGROUND Conflicting reports about the toxicity of Synedrella nodiflora (L) Gaertn (family Asteraceae), a plant traditionally used in Ghana for the management of epilepsy, abound in literature. The present study evaluates the effect of a 90-day continuous oral administration of a hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) in male Sprague-Dawley rats. METHODS The toxic...

BACKGROUND Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative reviews are rare; this one evaluates the effects of chlorpromazine in the treatment of schizophrenia in comparison with placebo. METHODS We sought all relevant randomised controlled trials (RCT) compari...