Chloroform and other trihalomethanes are contaminants of drinking water that have been demonstrated to be carcinogenic in laboratory animals. Determination of the mechanism of carcinogenicity of chloroform is required so that the animal data can be extrapolated to estimate the human health hazard. The extent of the binding of chloroform to rat liver and kidney DNA was approximately 0.1% the lev...

Japanese medaka (Oryzias latipes) were continually exposed in a flow-through diluter system for 9 months to measured chloroform concentrations of 0.017, 0.151, or 1.463 mg/L. Parameters evaluated were hepatocarcinogenicity, hepatocellular proliferation, hematology, and intrahepatic chloroform concentration. Histopathology was evaluated at 6 and 9 months. Chloroform was not hepatocarcinogenic to...

Poisoning by chloroform is of very rare occurrence, especially when it is drunk. The report-, of the following case has been taken from my friend. Baboo Girish Ghunder Chatterjee, SubAssistant Surgeon in charge of the Maharajah of Yizianagram's Dispensary at Bheloopore, in the suburbs of Benares. A jemadar, by name Jngmohone, aged 40, in the service of the Maharajah of Nattore, took about an ou...

The question of which is the best and safest general anaesthetic continues to be constantly brought under the notice of the profession by the frequent occurrence of deaths during anaesthesia. The fact that opinions are still so divided shows that a good deal can be said in favour of both chloroform and ether; but one thing stands out pre-eminently, and that is, that when deaths do occur they ar...

During a discussion in the early part of the present session, at the Westminster Medical Society, when a paper was read by Professor Murphy, advocating the use of chloroform in midwifery, Dr. Webster, according to the reports published in the medical journals, mentioned three cases of insanity supervening after the employment of the above powerful agent during childbirth; to which he afterwards...

Chlorination of pool water leads to the formation of many by-products, chloroform usually being the most abundant. The paper reports the results of a study evaluating exposure of bathers and pool employees to trihalomethanes (chloroform, bromodichloromethane, dibromochloromethane, bromoform) in four indoor swimming pools with chlorinated water. Chloroform concentrations in environmental air sam...