نتایج جستجو برای: chitosan and trimethylchitosan nanoparticles
تعداد نتایج: 16861549 فیلتر نتایج به سال:
The need of natural antimicrobials is paramount to avoid harmful synthetic chemicals. The study aimed to determine the antifungal activity of natural compound chitosan and its nanoparticles forms against Candida albicans, Fusarium solani and Aspergillus niger. Chitosan nanoparticles were prepared from low (LMW), high molecular weight (HMW) chitosan and its derivative, trimethyl chitosan (TMC). ...
in recent years, utilization of chitosan /tripolyphosphate nanoparticles has been considered greatly as protein delivery vehicles. effects of a variety of factors on final characteristics of nanoparticles have been studied by many investigators. although, the objective of this study was to achieve smaller chitosan nano carriers via changing fabrication parameters such as ph and temperature and ...
Nanoscale particles offer a variety of interesting properties, and there is growing interest in their assembly into higher ordered structures. We report that the pH-responsive aminopolysaccharide chitosan can mediate the electrodeposition of model nanoparticles. Chitosan is known to electrodeposit at the cathode surface in response to a high localized pH. To demonstrate that chitosan can mediat...
Magnetic chitosan nanoparticles were prepared by the suspension cross-linking technique for use in the application of magnetic carrier technology. The Fe3O4 magnetic nanoparticles were synthesized by co-precipitation of FeCl2 and FeCl3 solution in base medium for using in the preparation of the magnetic chitosan. The morphological and magnetic properties of the magnetic nanoparticles were chara...
This study reports that tumor-targeting glycol chitosan nanoparticles with physically loaded and chemically conjugated photosensitizers can be used in photodynamic therapy (PDT). First, the hydrophobic photosensitizer, chlorin e6 (Ce6), was physically loaded onto the hydrophobically-modified glycol chitosan nanoparticles (HGC), which were prepared by self-assembling amphiphilic glycol chitosan-...
objective(s): interleukin-12 (il-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. the objective of the...
Chitosan is an attractive natural biopolymer from renewable resources with the presence of reactive amino and hydroxyl functional groups in its structure. Due to the good biocompatibility of chitosan, it can be used in magnetic-field assisted drug delivery, enzyme or cell immobilization and many other industrial applications. In the past decade, nanotechnology has been a considerable research i...
background and objectives: the most prevalent and worldwide oral disease is dental caries that affects a significant pro- portion of the world population. there are some classical approaches for control, prevention and treatment of this pathologic condition; however, the results are still not completely successful. therefore new methods are needed for better management of this important challen...
Gene therapy targeted at the respiratory epithelium holds therapeutic potential for diseases such as cystic fibrosis and lung cancer. We recently reported that Chitosan-DNA-FAP-B nanoparticles are good candidates for targeted gene delivery to fibronectin molecules (FAP-B receptors) of lung epithelial cell membrane. In this study Chitosan-DNA-FAP-B nanoparticles were nebulized to mice using air ...
The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing.
We have previously introduced the use of the biomaterial chitosan to form chitosan/siRNA nanoparticles for gene silencing protocols. This present study shows that the physicochemical properties (size, zeta potential, morphology and complex stability) and in vitro gene silencing of chitosan/siRNA nanoparticles are strongly dependent on chitosan molecular weight (Mw) and degree of deacetylation (...
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