Metacognitive awareness has been shown to be a critical skill for academic success. However, students often struggle to regulate this ability during learning tasks. The current study investigates how features designed to promote metacognitive awareness can be built into the game-based intelligent tutoring system (ITS) iSTART-2. College students (n=28) interacted with iSTART-2 for one hour, comp...

We propose heading-aware methods of generating search result snippets of web pages. A heading is a brief description of the topic of its associated sentences. Some existing methods give priority to sentences containing many words that also appear in headings when selecting sentences to be included in snippets with limited length. However, according to our observation, words in heading are very ...

Phenomena in the performance behaviour of high-performance computing (HPC) applications can stem from the HPC system itself, from the application’s code, but also from the simulation domain. In order to analyse the latter phenomena, we propose a system that visualizes profile-based performance data in its spatial context, i.e., on the geometry, in the simulation domain. It thus helps HPC expert...

An accurate, simple and reproducible high-performance liquid chromatographic (HPLC) method has been developed and validated for the direct separation of individual enantiomers of Abacavir sulfate, a nucleoside reverse transcriptase inhibitor for the treatment of HIV, in pharmaceutical bulk drugs. The enantiomers were resolved by normal phase chromatography, on Chiralpak IA column by using a mob...

The chromatographic resolution of pregabalin enantiomers has been often achieved by derivatization of the molecule, in order to reach enough sensitivity at low concentrations of the minor enantiomer present in the active principle. In the present article, the development and optimization of two liquid chromatographic methods are presented for the direct resolution of pregabalin enantiomers on a...

An efficient methodology for the preparation of the α-tetrasubstituted proline analog (S,S,S)-2-methyloctahydroindole-2-carboxylic acid, (S,S,S)-(αMe)Oic, and its enantiomer, (R,R,R)-(αMe)Oic, has been developed. Starting from easily available substrates and through simple transformations, a racemic precursor has been synthesized in excellent yield and further subjected to HPLC resolution using...

CHIRALPAK QN-AX and QD-AX are anion exchanger chiral stationary phases providing specifi c enantioselectivity for acidic compounds. In this Application Note, we demonstrate that the application of these columns can be extended to supercritical fl uid chromatography (SFC) for enantiomer separation of acidic compounds. Using the advantages of the advanced technology of the Agilent 1260 Infi nity ...